治疗性癌症疫苗在帮助癌症患者进行免疫治疗方面显示出良好的功效，但缺乏临床应用的系统表征和提高疗效的方法。在此，我们主要总结治疗性癌症疫苗的分类，包括蛋白质疫苗、核酸疫苗、细胞疫苗和抗独特型抗体疫苗，并根据不同类型和递送形式对上述疫苗进行细分。此外，我们概述了疫苗的临床功效和安全性，以及治疗性癌症疫苗与其他疗法的联合策略。本综述将为治疗性癌症疫苗的未来临床应用和开发提供详细的概述和基本原理。版权所有 © 2023 Elsevier B.V. 保留所有权利。

Therapeutic cancer vaccines have shown promising efficacy in helping immunotherapy for cancer patients, but the systematic characterization of the clinical application and the method for improving efficacy is lacking. Here, we mainly summarize the classification of therapeutic cancer vaccines, including protein vaccines, nucleic acid vaccines, cellular vaccines and anti-idiotypic antibody vaccines, and subdivide the above vaccines according to different types and delivery forms. Additionally, we outline the clinical efficacy and safety of vaccines, as well as the combination strategies of therapeutic cancer vaccines with other therapies. This review will provide a detailed overview and rationale for the future clinical application and development of therapeutic cancer vaccines.Copyright © 2023 Elsevier B.V. All rights reserved.