转移是癌症进展中最危险的问题之一，其特点是入侵的肿瘤细胞、各种蛋白质和其他细胞在到达目标部位的过程中之间存在复杂的相互作用。肿瘤细胞在发生转移时，会与基质细胞进行动态对话，并进行上皮间质转化（EMT）表型转化。为了确保生存，肿瘤细胞采用多种策略，例如通过巨自噬（autophagy）等不同机制重组其代谢需求以适应微环境资源的变化，并避免失巢凋亡（anoikis）——一种与细胞外基质分离时诱导的细胞死亡形式。细胞外基质）。本综述重点关注癌症转移背景下自噬和能量代谢之间令人费解的联系。版权所有 © 2023。由 Elsevier B.V. 出版。

Metastasis represents one of the most dangerous issue of cancer progression, characterized by intricate interactions between invading tumor cells, various proteins, and other cells on the way towards target sites. Tumor cells, while undergoing metastasis, engage in dynamic dialogues with stromal cells and undertake epithelial-mesenchymal transition (EMT) phenoconversion. To ensure survival, tumor cells employ several strategies such as restructuring their metabolic needs to adapt to the alterations of the microenvironmental resources via different mechanisms including macroautophagy (autophagy) and to circumvent anoikis-a form of cell death induced upon detachment from the extracellular matrix (ECM). This review focuses on the puzzling connections of autophagy and energetic metabolism within the context of cancer metastasis.Copyright © 2023. Published by Elsevier B.V.