本研究旨在系统回顾有关全球寻求放射治疗的患者旅行模式的文献。它分析了患者接受放疗的出行距离及其对次要结果（包括出行时间）的影响。从 2022 年 6 月到 2022 年 8 月对四个数据库进行了全面检索。如果研究是观察性、回顾性、随机/非研究，则纳入该综述。 - 随机，2000 年 6 月至 2022 年 6 月期间发布，以及是否报告了恶性或良性疾病放射治疗的全球行进距离。如果研究没有报告旅行距离或不是用英语撰写，则被排除在外。 在 169 项研究中，大多数研究在北美进行（76.3%），其中 90.7% 在美国进行。用于治疗乳腺癌患者的放射治疗研究是最常见的（26.6%），而外照射放射治疗是最普遍的治疗方式（16.6%）。 46 项研究报告了放射治疗的平均行进距离，其中最短的是美国的 4.8 英里，最长的是伊朗的 276.5 英里。据观察，美国境外的患者比美国境内的患者旅行的距离更远。地理位置、城市与农村居住情况以及患者人口都会影响患者接受放射治疗的出行距离。本系统综述对全球寻求放射治疗的患者的出行模式进行了最全面的总结。结果表明，多种因素可能导致旅行距离模式的变化，包括治疗中心位置、国家、患者居住地和治疗方式。总体而言，该研究强调需要进行更多研究来探索这些因素，并制定有效的策略来改善放射治疗的可及性和减轻旅行负担。版权所有 © 2023。由 Elsevier Inc. 出版。

This study aims to systematically review the literature on the travel patterns of patients seeking radiotherapy globally. It analyzes the distance patients travel for radiotherapy and its impact on secondary outcomes, including travel time.A comprehensive search of four databases was conducted from June 2022 to August 2022. Studies were included in the review if they were observational, retrospective, randomized/non-randomized, published between June 2000 and June 2022, and if the distance traveled globally for radiotherapy treatment of malignant or benign disease was reported. Studies were excluded if they did not report travel distance or were not written in English.Of the 169 studies, most were conducted in North America (76.3%), with 90.7% based in the United States. Radiotherapy studies for treating breast cancer patients were the most common (26.6%), while external beam radiation therapy was the most prevalent treatment modality (16.6%). Forty-six studies reported the mean distance traveled for radiation therapy, with the shortest being 4.8 miles in the United States and the longest being 276.5 miles in Iran. It was observed that patients outside of the United States traveled greater distances than those living within the United States. Geographic location, urban versus rural residence, and patient population affected the distance patients traveled for radiotherapy.This systematic review provides the most extensive summary of the travel patterns of patients seeking radiotherapy globally. The results suggest that various factors may contribute to the variability in travel distance patterns, including treatment center location, country, patient residence, and treatment modality. Overall, the study highlights the need for more research to explore these factors and to develop effective strategies for improving radiotherapy access and reducing travel burden.Copyright © 2023. Published by Elsevier Inc.