胰腺癌（PC）通常在相对晚期诊断，预后较差，是全世界癌症相关死亡的主要原因。越来越多的证据表明，环状RNA（circRNA）在多种肿瘤中异常表达，并影响肿瘤的发生和进展。在本文中，我们研究了 circRNA 在调节 PC 进展中的作用。此外，富含外泌体的circRNA可以在PC细胞之间转移以调节恶性肿瘤。涉及一般 circRNA 和具体 PC 的调控机制的表征将有助于更早检测和治疗策略的潜在开发。版权所有 © 2023 Elsevier B.V. 保留所有权利。

Pancreatic cancer (PC), typically diagnosed at relatively advanced stages with poor prognosis, is a dominant cause of cancer-related deaths worldwide. Accumulating evidence demonstrates that circular RNAs (circRNAs) are abnormally expressed in diverse tumors and affect tumorigenesis and progression. In this article, we examine the roles of circRNAs in regulation of PC progression. Additionally, circRNAs enriched in exosomes could be transferred among PC cells to modulate malignancy. Characterization of regulatory mechanisms involving circRNAs in general and PC specifically will enable earlier detection and potential development of therapeutic strategies.Copyright © 2023 Elsevier B.V. All rights reserved.