剖析本质上无序蛋白质的生物物理学和生物学。
Dissecting the biophysics and biology of intrinsically disordered proteins.
发表日期：2023 Nov 08
作者：
Priya R Banerjee, Alex S Holehouse, Richard Kriwacki, Paul Robustelli, Hao Jiang, Alexander I Sobolevsky, Jennifer M Hurley, Joshua T Mendell
来源：
TRENDS IN BIOCHEMICAL SCIENCES
摘要：
人类蛋白质内的内在无序区域 (IDR) 在细胞信息处理中发挥着关键作用，包括信号传导、转录、应激反应、DNA 修复、基因组组织和 RNA 处理。在这里，我们总结了该领域当前的挑战，并提出了解决生理学和疾病过程中这些挑战的前沿方法，重点是癌症。版权所有 © 2023 Elsevier Ltd. 保留所有权利。
Intrinsically disordered regions (IDRs) within human proteins play critical roles in cellular information processing, including signaling, transcription, stress response, DNA repair, genome organization, and RNA processing. Here, we summarize current challenges in the field and propose cutting-edge approaches to address them in physiology and disease processes, with a focus on cancer.Copyright © 2023 Elsevier Ltd. All rights reserved.