腹泻是人体水分排泄增加以及小肠和大肠生理过程失衡所致，而莽草酸是植物中重要的生化代谢产物。本研究旨在通过恢复饲喂乳糖饮食诱导腹泻的SD大鼠的肾功能、抗氧化活性、炎症标志物、钠/钾-ATP酶活性、凋亡基因和肾脏组织学来研究莽草酸的抗腹泻活性。 30 -将6只雄性SD大鼠（150±10g，12周龄）分为2个相等的组（18只/组），如下：正常大鼠和腹泻大鼠。将正常大鼠分为3个相等的组，每组6只大鼠：对照组、莽草酸组和去氨加压素药物组。将腹泻大鼠也分为3个相等的组，每组6只大鼠：腹泻大鼠、腹泻大鼠 莽草酸组和腹泻大鼠  去氨加压素药物组。莽草酸可恢复血清尿素和肌酐、尿量、肾脏重量、血清和尿液中钠、钾和氯的平衡。酸恢复了抗氧化剂（超氧化物歧化酶、谷胱甘肽过氧化物酶、过氧化氢酶、丙二醛、NADPH 氧化酶活性、共轭二烯和氧化指数）活性和炎症标志物（肿瘤坏死因子-α、白细胞介素-1β、白细胞介素-6 和白细胞介素- 10) 使值接近控制值。莽草酸还能恢复腹泻大鼠的钠/钾-ATP酶活性、凋亡基因p53和bcl-2，并使肾组织的组织学接近对照组。莽草酸通过恢复肾功能、血清功能来缓解腹泻及其并发症。以及尿液电解质、抗氧化活性、炎症标志物、钠/钾-ATP 酶活性、凋亡基因以及腹泻大鼠肾脏的组织学，以接近对照组。© 2023。作者。

Diarrhea is the increase of excretion of human water content and an imbalance in the physiologic processes of the small and large intestine while shikimic acid is an important biochemical metabolite in plants. This study aims to study the anti-diarrheal activity of shikimic acid through restoring kidney function, antioxidant activity, inflammatory markers, sodium/potassium-ATPase activity, apoptosis genes, and histology of the kidney in SD rats fed lactose diet to induce diarrhea.Thirty-six male SD rats (150 ± 10 g, 12 weeks old) were divided into 2 equal groups (18 rats/group) as follows: normal and diarrheal rats. Normal rats were divided into 3 equal groups of 6 rats each: the control, shikimic acid, and desmopressin drug groups. Diarrheal rats were also divided into 3 equal groups of 6 rats each: diarrheal, diarrheal rats + shikimic acid, and diarrheal rats + desmopressin drug groups. Shikimic acid restored serum urea and creatinine, urinary volume, kidney weight, sodium, potassium, and chloride balance in serum and urine. The acid returned the antioxidant (superoxide dismutase, glutathione peroxidase, catalase, malondialdehyde, NADPH oxidase activity, conjugated dienes, and oxidative index) activity and the inflammatory markers (tumor necrosis factor-α, interleukin-1β, interleukin-6, and interleukin-10) to values approaching the control values. Shikimic acid also restored the sodium/potassium-ATPase activity, the apoptosis genes p53 and bcl-2, and the histology of kidney tissue in diarrheal rats to be near the control group.Shikimic acid rescues diarrhea and its complications through restoring kidney function, serum and urinary electrolytes, antioxidant activity, inflammatory markers, sodium/potassium-ATPase activity, the apoptosis genes, and the histology of the kidney in diarrheal rats to approach the control one.© 2023. The Author(s).