广泛使用的磁化准备快速梯度回波（MPRAGE）序列使增强的病灶和血管在钆给药后显得明亮。然而，使用 T1 加权采样完美和使用不同翻转角进化 (T1 SPACE) 的应用优化对比度的暗血液成像可能是有利的，因为它提高了小转移瘤和软脑膜疾病的明显性。作为 T1 SPACE 的潜在替代方案，我们评估了一种称为 echo-uT1 RESS（不平衡 T1 松弛增强稳态）的新暗血序列。我们将 echo-uT1 RESS 与 Dixon fid-uT1 RESS、MPRAGE 和T1 SPACE。回顾性，IRB 批准。用于评估 echo-uT1 RESS 流量特性的体模。 21 名患有原发性和继发性脑肿瘤的患者（14 名女性，年龄范围 35-82 岁）。3 Tesla/MPRAGE、T1 SPACE、Dixon fid-uT1 RESS、echo-uT1 RESS。流幻象信号与速度作为函数翻转角度和顺序。 4 分制的定性图像评估。肿瘤与大脑对比、表观对比噪声比 (aCNR) 和血管与大脑 aCNR 的定量评估。Friedman 和 Mann-Whitney U 检验。 P 值 <0.05 被认为具有统计学意义。在体模中，echo-uT1 RESS 显示出比 fid-uT1 RESS 更大的流量依赖性信号丢失。在患者中，MPRAGE 时血管呈明亮状态，fid-uT1 RESS 时血管呈灰色，T1 SPACE 和 echo-uT1 RESS 时血管呈黑色。对于MPRAGE、Dixon fid-uT1 RESS、echo-uT1 RESS和T1 SPACE，肿瘤与脑的对比值分别为0.6±±0.3、1.3±0.5、1.0±0.4和0.6±0.4，而标准化aCNR值为68.9 ± 50.9、128.4 ± 59.2、74.2 ± 42.1 和 99.4 ± 73.9。使用 echo-uT1 RESS 进行体积暗血对比增强脑 MRI 是可行的。与 fid-uT1 RESS 相比，暗血效果得到改善，而两个 uT1 RESS 版本都提供了比 MPRAGE 更好的肿瘤与大脑对比度。 T1 SPACE 提供了更好的肿瘤 aSNR，而 echo-uT1 RESS 提供了更好的韦伯对比度、病变清晰度和更一致的暗血效果。3 技术功效：第 1 阶段。© 2023 作者。 《磁共振成像杂志》由 Wiley periodicals LLC 代表国际医学磁共振学会出版。

The widely used magnetization-prepared rapid gradient-echo (MPRAGE) sequence makes enhancing lesions and blood vessels appear bright after gadolinium administration. However, dark blood imaging using T1-weighted Sampling Perfection with Application optimized Contrast using different flip angle Evolution (T1 SPACE) can be advantageous since it improves the conspicuity of small metastases and leptomeningeal disease. As a potential alternative to T1 SPACE, we evaluated a new dark blood sequence called echo-uT1 RESS (unbalanced T1 Relaxation-Enhanced Steady-State).We compared the performance of echo-uT1 RESS with Dixon fid-uT1 RESS, MPRAGE, and T1 SPACE.Retrospective, IRB approved.Phantom to assess flow properties of echo-uT1 RESS. Twenty-one patients (14 female, age range 35-82 years) with primary and secondary brain tumors.3 Tesla/MPRAGE, T1 SPACE, Dixon fid-uT1 RESS, echo-uT1 RESS.Flow phantom signal vs. velocity as a function of flip angle and sequence. Qualitative image assessment on 4-point scale. Quantitative evaluation of tumor-to-brain contrast, apparent contrast-to-noise ratio (aCNR), and vessel-to-brain aCNR.Friedman and Mann-Whitney U tests. A P value <0.05 was considered statistically significant.In the phantom, echo-uT1 RESS showed greater flow-dependent signal loss than fid-uT1 RESS. In patients, blood vessels appeared bright with MPRAGE, gray with fid-uT1 RESS, and dark with T1 SPACE and echo-uT1 RESS. For MPRAGE, Dixon fid-uT1 RESS, echo-uT1 RESS, and T1 SPACE, respective tumor-to-brain contrast values were 0.6 ± 0.3, 1.3 ± 0.5, 1.0 ± 0.4, and 0.6 ± 0.4, while normalized aCNR values were 68.9 ± 50.9, 128.4 ± 59.2, 74.2 ± 42.1, and 99.4 ± 73.9.Volumetric dark blood contrast-enhanced brain MRI is feasible using echo-uT1 RESS. The dark blood effect was improved vs. fid-uT1 RESS, while both uT1 RESS versions provided better tumor-to-brain contrast than MPRAGE. Whereas T1 SPACE provided better tumor aSNR, echo-uT1 RESS provided better Weber contrast, lesion sharpness and a more consistent dark blood effect.3 TECHNICAL EFFICACY: Stage 1.© 2023 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.