导致早期放疗（RT）终止的潜在因素尚未得到充分研究，特别是在大分割治疗方案时代。在这项回顾性调查中，我们研究了患有口腔（OC）和喉癌的老年人（> 70岁）提前终止放疗的特征和原因。188名接受RT± 系统治疗的OC和喉癌患者2017 年至 2022 年的癌症被确定。提前终止被定义为完成少于规定 RT 的 95%。进行逻辑回归分析以检查预测提前终止的因素，并使用 Kaplan-Meier 方法确定生存率。20 名患者 (10.6%) 经历过提前终止 RT。在回归分析中，RT 开始时的 ECOG 评分是研究中唯一与提前终止独立相关的协变量（OR 2.00，95%CI：[1.21，3.30]，p = 0.007）。终止队列中的三年总生存率（49.1% vs. 77.3%）显着降低（p<0.0001）。该分析表明，超过十分之一的患者提前终止 RT，这预示生存结果较差。表现状态不佳可能会凸显患者面临提前终止的风险，从而确定大分割方案的良好候选者。© 2023 Wiley periodicals LLC。

The underlying factors that contribute to early radiotherapy (RT) termination are understudied, especially in the era of hypofractionated treatment regimens. In this retrospective investigation, we examined the characteristics and causes of premature RT terminations in senior adults (>70 years old) with oral cavity (OC) and laryngeal carcinomas.Hundred and eighty-eight patients treated with RT ± systemic therapy for OC and laryngeal cancer from 2017 to 2022 were identified. Premature termination was defined as completion of less than 95% of the prescribed RT. Logistic regression analysis was performed to examine factors predictive of premature termination, and survival was determined using the Kaplan-Meier method.Twenty patients (10.6%) experienced premature RT terminations. On regression analysis, ECOG score at initiation of RT was the only covariate studied to be independently associated with premature termination (OR 2.00, 95%CI: [1.21, 3.30], p = 0.007). Three-year overall survival (49.1% vs. 77.3%) was significantly reduced in the termination cohort (p < 0.0001).This analysis demonstrated over 1 in 10 patients had premature RT termination, which prognosticated inferior survival outcomes. Poor performance status may highlight patients at risk for premature termination and thus identify good candidates for hypofractionated protocols.© 2023 Wiley Periodicals LLC.