慢性炎症是许多重大疾病的常见潜在因素，包括心脏病、糖尿病、癌症和自身免疫性疾病，并且导致全球死亡人数高达 60%。二甲双胍、他汀类药物、皮质类固醇和 NSAID（非甾体类抗炎药）通常作为抗炎药物使用，但它们往往具有比疾病本身更严重的副作用。与替代传统抗炎药物相比，基于天然产物的炎症相关疾病治疗没有副作用且具有良好的有益效果。在这篇综述文章中，我们对当前的药物治疗、炎症的病理生理学及其背后的信号通路进行了简要概述。此外，我们还专注于被确定为潜在抗炎治疗剂的最有前途的天然产品。此外，还回顾了评估天然产物作为抗炎治疗剂的功效及其具有良好结果的实际应用的临床前研究和临床试验。此外，还讨论了天然产物的安全性、副作用和技术壁垒。此外，我们还总结了基于天然产物的医学发现和科学开发的最新技术进展。© 2023。作者，获得 Springer Nature Switzerland AG 的独家许可。

Chronic inflammation is a common underlying factor in many major diseases, including heart disease, diabetes, cancer, and autoimmune disorders, and is responsible for up to 60% of all deaths worldwide. Metformin, statins, and corticosteroids, and NSAIDs (non-steroidal anti-inflammatory drugs) are often given as anti-inflammatory pharmaceuticals, however, often have even more debilitating side effects than the illness itself. The natural product-based therapy of inflammation-related diseases has no adverse effects and good beneficial results compared to substitute conventional anti-inflammatory medications. In this review article, we provide a concise overview of present pharmacological treatments, the pathophysiology of inflammation, and the signaling pathways that underlie it. In addition, we focus on the most promising natural products identified as potential anti-inflammatory therapeutic agents. Moreover, preclinical studies and clinical trials evaluating the efficacy of natural products as anti-inflammatory therapeutic agents and their pragmatic applications with promising outcomes are reviewed. In addition, the safety, side effects and technical barriers of natural products are discussed. Furthermore, we also summarized the latest technological advances in the discovery and scientific development of natural products-based medicine.© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.