长非编码 RNA (lncRNA) 已成为基因表达的关键调节因子，对包括细胞凋亡在内的多种细胞过程做出了显着贡献。其中一种 lncRNA 是 NEAT1，它在多种类型的癌症中表达升高，并有助于癌症生长。然而，最近的研究也表明，NEAT1的敲低可以抑制癌细胞的增殖、运动和浸润，同时增强细胞凋亡。本文探讨了 lncRNA NEAT1 敲低在调节多种癌症类型细胞凋亡中的功能。我们探讨了对 NEAT1 参与恶性疾病进展的现有理解，包括其结构和功能。此外，我们还研究了 NEAT1 调节多种癌症类型的细胞周期、细胞增殖、凋亡、运动和浸润的分子机制，包括急性髓系白血病、乳腺癌、宫颈癌、结直肠癌、食管鳞状细胞癌、神经胶质瘤、非小细胞肺癌、卵巢癌、前列腺癌和视网膜母细胞瘤。此外，我们回顾了最近研究 NEAT1 敲低在癌症治疗中的治疗潜力的研究。靶向 lncRNA NEAT1 为治疗癌症提供了一种有前景的治疗方法。它已显示出能够抑制癌细胞增殖、迁移和侵袭，同时促进各种癌症类型的细胞凋亡。版权所有 © 2023 Elsevier GmbH。版权所有。

Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators of gene expression, contributing significantly to a diverse range of cellular processes, including apoptosis. One such lncRNA is NEAT1, which is elevated in several types of cancer and aid in cancer growth. However, recent studies have also demonstrated that the knockdown of NEAT1 can inhibit cancer cells proliferation, movement, and infiltration while enhancing apoptosis. This article explores the function of lncRNA NEAT1 knockdown in regulating apoptosis across multiple cancer types. We explore the existing understanding of NEAT1's involvement in the progression of malignant conditions, including its structure and functions. Additionally, we investigate the molecular mechanisms by which NEAT1 modulates the cell cycle, cellular proliferation, apoptosis, movement, and infiltration in diverse cancer types, including acute myeloid leukemia, breast cancer, cervical cancer, colorectal cancer, esophageal squamous cell carcinoma, glioma, non-small cell lung cancer, ovarian cancer, prostate cancer, and retinoblastoma. Furthermore, we review the recent studies investigating the therapeutic potential of NEAT1 knockdown in cancer treatment. Targeting the lncRNA NEAT1 presents a promising therapeutic approach for treating cancer. It has shown the ability to suppress cancer cell proliferation, migration, and invasion while promoting apoptosis in various cancer types.Copyright © 2023 Elsevier GmbH. All rights reserved.