三阴性乳腺癌（TNBC）是最具侵袭性的乳腺癌形式，对女性健康构成严重威胁。因此，寻找新的治疗方法至关重要。铁死亡是一种新发现的程序性细胞死亡形式，其特征是脂质活性氧（ROS）的积累和高铁浓度。根据先前的研究，铁死亡敏感性可以通过细胞内的许多代谢事件来控制，例如氨基酸代谢、铁代谢和脂质代谢。鉴于 TNBC 肿瘤富含铁和脂质，在这些肿瘤中诱导铁死亡是 TNBC 治疗的一种潜在方法。值得注意的是，癌细胞的代谢适应性使其能够协调对一个或多个代谢途径的攻击以引发铁死亡，为提高TNBC的高耐药性和临床治疗提供了新的视角。然而，TNBC 中铁死亡的清晰图像仍然需要完全揭示。在这篇综述中，我们概述了 TNBC 中铁死亡与氨基酸、铁和脂质代谢之间关系的最新进展。我们还讨论了铁死亡作为 TNBC 化疗、放疗、免疫治疗、纳米疗法和天然产物疗法的创新靶点的可能意义，强调了其治疗潜力和应用前景。版权所有 © 2023 作者。由 Elsevier Masson SAS 出版。保留所有权利。

Triple-negative breast cancer (TNBC), the most aggressive form of breast cancer, presents severe threats to women's health. Therefore, it is critical to find novel treatment approaches. Ferroptosis, a newly identified form of programmed cell death, is marked by the buildup of lipid reactive oxygen species (ROS) and high iron concentrations. According to previous studies, ferroptosis sensitivity can be controlled by a number of metabolic events in cells, such as amino acid metabolism, iron metabolism, and lipid metabolism. Given that TNBC tumors are rich in iron and lipids, inducing ferroptosis in these tumors is a potential approach for TNBC treatment. Notably, the metabolic adaptability of cancer cells allows them to coordinate an attack on one or more metabolic pathways to initiate ferroptosis, offering a novel perspective to improve the high drug resistance and clinical therapy of TNBC. However, a clear picture of ferroptosis in TNBC still needs to be completely revealed. In this review, we provide an overview of recent advancements regarding the connection between ferroptosis and amino acid, iron, and lipid metabolism in TNBC. We also discuss the probable significance of ferroptosis as an innovative target for chemotherapy, radiotherapy, immunotherapy, nanotherapy and natural product therapy in TNBC, highlighting its therapeutic potential and application prospects.Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.