尽管外阴鳞状细胞癌（VSCC）主要是老年女性的一种疾病，但人们对老年女性外阴鳞状细胞癌（VSCC）的临床治疗知之甚少。我们与年轻女性相比评估了她们的日常临床管理，并确定了合并症的患病率及其对总生存期 (OS) 的影响。2015 年至 2020 年诊断为 VSCC 的所有荷兰女性 (n = 2249) 均选自荷兰癌症登记处。年龄≥80 岁的女性（n = 632，28%）被定义为“老年”患者，<80 岁的女性被视为“年轻”患者。进行卡方检验以评估不同年龄组和合并症的治疗差异。使用 Kaplan-Meier 曲线和时序检验评估 OS 差异。绝大多数老年 (91%) 和年轻 (99%) 的FIGO IA VSCC 患者都接受了外阴手术治疗。与年轻患者相比，老年 Figo IB-IV VSCC 患者接受腹股沟手术的可能性较小（50% vs. 84%，p < 0.01）。外阴和腹股沟的手术治疗效果与老年患者的合并症数量无关（p = 0.67 和 p = 0.69）。与只有一种或没有一种合并症的女性相比，患有 ≥2 种合并症的老年患者的 OS 确实较差 (p < 0.01)。绝大多数老年患者接受了外阴/局部手术。与年轻患者相比，老年患者较少接受腹股沟手术。大多数老年患者至少患有一种合并症，但这并不影响治疗选择。因此，老年 VSCC 患者的生存率较差可能是由于竞争风险导致的死亡，而不是 VSCC 本身。版权所有 © 2023。由 Elsevier Inc. 出版。

Despite being a disease of mainly older women, little is known about the clinical management of older women with vulvar squamous cell carcinoma (VSCC). We evaluated their daily clinical management compared with younger women, and established the prevalence of comorbidities and its impact on overall survival (OS).All Dutch women diagnosed with VSCC from 2015 to 2020 (n = 2249) were selected from the Netherlands Cancer Registry. Women aged ≥80 years (n = 632, 28%) were defined as "older" patients, women <80 years were considered as "younger". Chi-square tests were performed to evaluate differences in treatment by age group and comorbidities. Differences in OS were evaluated using Kaplan-Meier Curves and log-rank test.The vast majority of both older (91%) and younger (99%) patients with FIGO IA VSCC received surgical treatment of the vulva. Older FIGO IB-IV VSCC patients were less likely to undergo groin surgery than younger patients (50% vs. 84%, p < 0.01). Performance of surgical treatment of the vulva and groin(s) was not associated with the number of comorbidities in older patients (p = 0.67 and p = 0.69). Older patients with ≥2 comorbidities did have poorer OS compared to women with one or no comorbidities (p < 0.01).The vast majority of older patients underwent vulvar/local surgery. Older patients less often received groin surgery compared to younger patients. The majority of older patients had at least one comorbidity, but this did not impact treatment choice. The poorer survival in older VSCC patients may therefore be due to death of competing risks instead of VSCC itself.Copyright © 2023. Published by Elsevier Inc.