口腔鳞状细胞癌（OSCC）是口腔中最常见的癌症，占口腔癌的 90%，全球每年新发病例 35 万例。根治性切除联合辅助放射治疗或放射治疗与化疗相结合仍然是治疗 OSCC 的金标准。尽管如此，局部复发、淋巴结复发和放射并发症仍然是肿瘤相关死亡的主要原因。活性氧不仅与由于氧化 DNA 损伤、脂质过氧化或影响细胞增殖和肿瘤发生的信号转导级联而导致的 OSCC 病因相关，而且在 OSCC 患者的治疗中也具有重要意义。由于诱导的氧化应激可在治疗上用于诱导肿瘤细胞死亡，因此氧化还原靶标可能是常规治疗方案的治疗补充。在这篇综述中，我们讨论了 OSCC 中氧化还原稳态受损的标志物以及潜在的氧化还原相关治疗目标。版权所有 © 2023 Elsevier Ltd。保留所有权利。

Oral squamous cell carcinoma (OSCC) is the most common cancer in the oral cavity accounting for 90 % of oral cancer with a global incidence of 350.000 new cases per year. Curative resection along with adjuvant radiation therapy or a combination of radiotherapy with chemotherapy remain as gold standard in treating OSCC. Still, local recurrence, lymph nodal recurrence, and complications of radiation remain the main cause of tumor-related mortality. Reactive oxygen species are not only correlated to the etiology of OSCC due to oxidative DNA damage, lipid peroxidation or effecting signal transduction cascades that effect cell proliferation and tumorigenesis, but are also of great interest in the therapy of OSCC patients. As induced oxidative stress can be used therapeutically for the induction of tumor cell death, redox targets might be a therapeutic addition to the conventional treatment options. In this review, we discuss markers of impaired redox homeostasis as well as potential redox-related treatment targets in OSCC.Copyright © 2023 Elsevier Ltd. All rights reserved.