我们从携带种系 ATM 突变的乳腺癌患者的外周血单核细胞 (PBMC) 中生成了两种诱导多能干细胞 (iPSC) 系，该基因与乳腺癌的 7% 患病率相关。这些 iPSC 系表现出典型的形态，表达多能性标记，保持稳定的核型，并保留分化为三个胚层的能力。这些患者特异性 iPSC 系对于机制研究和开发旨在解决 ATM 相关癌症的药物筛选策略具有巨大潜力。版权所有 © 2023 作者。由 Elsevier B.V. 出版。保留所有权利。

We generated two induced pluripotent stem cell (iPSC) lines from peripheral blood mononuclear cells (PBMCs) of breast cancer patients carrying germline ATM mutations, a gene associated with a 7% prevalence in breast cancer. These iPSC lines displayed typical morphology, expressed pluripotency markers, maintained a stable karyotype, and retained the ability to differentiate into the three germ layers. These patient-specific iPSC lines hold great potential for mechanistic investigations and the development of drug screening strategies aimed at addressing ATM-related cancer.Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.