类固醇的硫酸化和脱硫是调节类固醇的活化、代谢、排泄和储存的相反过程，这解释了类固醇的稳态。类固醇硫酸化和脱硫分别由胞质磺基转移酶和类固醇硫酸酯酶催化。通过修饰和调节类固醇，胞质磺基转移酶（SULT）和类固醇硫酸酯酶（STS）也参与类固醇相关疾病的病理生理学，例如激素失调、代谢疾病和癌症。雌激素磺基转移酶（EST，或 SULT1E1）是类固醇 SULT 的典型成员。本综述旨在总结 SULT1E1 和 STS 在类固醇稳态和类固醇相关疾病中的作用。版权所有 © 2023。由 Elsevier Inc. 出版。

Sulfation and desulfation of steroids are opposing processes that regulate the activation, metabolism, excretion, and storage of steroids, which account for steroid homeostasis. Steroid sulfation and desulfation are catalyzed by cytosolic sulfotransferase and steroid sulfatase, respectively. By modifying and regulating steroids, cytosolic sulfotransferase (SULT) and steroid sulfatase (STS) are also involved in the pathophysiology of steroid-related diseases, such as hormonal dysregulation, metabolic disease, and cancer. The estrogen sulfotransferase (EST, or SULT1E1) is a typical member of the steroid SULTs. This review is aimed to summarize the roles of SULT1E1 and STS in steroid homeostasis and steroid-related diseases.Copyright © 2023. Published by Elsevier Inc.