子宫内膜癌（EC）定义了一组异质性肿瘤疾病，其起源于构成子宫内膜的子宫内膜细胞的转化。迄今为止，已经分析了几个分子靶标来描述该疾病的自然病程，克劳汀就是其中之一。紧密连接蛋白是紧密连接（TJ）的主要成分，其主要功能归因于通过细胞内离子扩散来划分组织和细胞间通讯：这些特征是上皮细胞的典型特征。它们的过度表达、错误定位或丢失会导致 EC 细胞的恶性。本综述收集了有关表达、调控和密蛋白相关信号通路的所有可用数据，以全面了解密蛋白对 EC 进展的影响。此外，还探索了 Claudin 差异表达的转化潜力，表明除了用于诊断和预后之外，它们在个性化医疗中的作用也可能有助于 EC 治疗。版权所有 © 2023。由 Elsevier B.V. 出版。

Endometrial carcinoma (EC) defines a heterogeneous group of neoplastic diseases originating from the transformation of endometrial cells that constitute the internal lining of the uterus. To date several molecular targets have been analysed to describe the natural course of the disease, claudins being among these. Claudins are the main components of tight junctions (TJs), and their main functions are ascribed to the compartmentalization of tissues and cell-cell communication by means of intracellular ions diffusion: these features are typical of epithelial cells. Their overexpression, mis-localization or loss contribute to the malignancy of EC cells. This review collected all available data regarding the expression, regulation and claudin-related signaling pathways to provide a comprehensive view on the influence of claudin in EC progression. Further, the translational potential of claudin differential expression was explored, indicating that their role in personalized medicine could also contribute to EC therapy besides their employment for diagnosis and prognosis.Copyright © 2023. Published by Elsevier B.V.