使用心脏 MRI 量化肺癌患者早期放疗 (RT) 引起的心脏和主动脉变化。9 名接受放疗治疗的肺癌患者在基线（放疗前）、放疗后 3 个月和放疗后 6 个月完成了 MR 扫描。获取电影、T1/T2、晚期钆增强 (LGE) 和 4D 流 MRI，以评估全球（即整个左心室 (LV) 或主动脉）和区域（根据美国心脏协会）的生物和机械心血管变化关联模型）。区域指标显示出多种显着变化和剂量依赖性反应。值得注意的是，LGE 在 3 个月和 6 个月时显示出间隔区域和高剂量区域的变化 (P<0.0458)。 3 个月时隔膜和高剂量区域以及 6 个月时隔膜区域的纵向应变变化显着（P<0.0469）。 3 个月时观察到 T1/T2 信号升高（P<0.0391）以及隔膜处径向/周向应变的变化（P<0.0391）。 T1/T2 信号和 LGE 均与 6 个月时的剂量相关（T1 信号也在 3 个月时），接受 >50 Gy 的区域变化显着更大（P<0.0331）。左心室剂量与左心室应变变化不相关（P>0.1），但升主动脉剂量与左心室第1段和第2段应变变化相关（P<0.0362）。全局指标仅识别出两个显着反应：6 个月时 LGE 体积增加和 3 个月时升主动脉环向应变减少 (P<0.0356)。放疗后早期基于 MR 的变化主要发生在高剂量区域和左室间隔墙。虽然一些早期信号在 6 个月内得到解决，但 LGE 和纵向应变变化至少持续了 6 个月。 6 个月时观察到 T1/T2/LGE 变化的剂量依赖性反应/相关性，在暴露于 >50 Gy 的区域影响最大。有必要对更大的队列和更长时间的随访进行进一步的研究，以确认区域剂量依赖性以及本试点研究中观察到的主动脉剂量与左室应变之间的关联。版权所有 © 2023。由爱思唯尔公司出版。

To quantify early radiotherapy (RT)-induced cardiac and aortic changes in patients with lung cancer using cardiac MRI.Nine patients with lung cancer treated with RT completed MR scans at baseline (before RT), 3 months, and 6 months following RT. Cine, T1/T2, late gadolinium enhancement (LGE), and 4D-flow MRIs were acquired to assess biological and mechanical cardiovascular changes globally (i.e., over the entire left ventricle (LV) or aorta) and regionally (according to an American Heart Association model).Regional metrics demonstrated multiple significant changes and dose-dependent responses. Notably, LGE showed changes at 3 and 6 months over septal and high-dose regions (P<0.0458). Longitudinal strain changes were notable at septal and high-dose regions at 3 months and septal regions at 6 months (P<0.0469). Elevated T1/T2 signals (P<0.0391) and changes in radial/circumferential strain at the septum (P<0.0391) were observed at 3 months. Both T1/T2 signal and LGE were correlated with dose at 6 months (T1 signal also at 3 months), with significantly greater changes in regions receiving >50 Gy (P<0.0331). LV dose was not correlated with LV strain changes (P>0.1), but ascending aortic dose was correlated with strain changes at segments 1 and 2 of the LV (P<0.0362). Global metrics identified only two significant responses: increase in LGE volume at 6 months and a reduction in ascending aortic circumferential strain at 3 months (P<0.0356).Early MR-based changes following RT occurred primarily in high-dose regions and the LV septal wall. While several early signals resolved by 6 months, LGE and longitudinal strain changes persisted for at least 6 months. Dose-dependent responses/correlations were observed for T1/T2/LGE changes at 6 months, with the greatest effect in regions exposed to >50 Gy. Further investigations with larger cohorts and longer follow-up are warranted to confirm regional dose dependence and the association between aortic dose and LV strain observed in this pilot study.Copyright © 2023. Published by Elsevier Inc.