自体造血干细胞移植（Auto-HSCT）广泛应用于血液肿瘤患者的治疗。由于这些细胞在外周少量循环，因此使用促进其动员的方案至关重要。在这项研究中，我们回顾性评估了使用中等剂量阿糖胞苷 (1.6 g/m²) 非格司亭 (10 mcg/kg/天) 动员 157 名接受统一医疗系统血液科治疗的患者干细胞的功效和安全性以及位于伯南布哥州累西腓的 Real Português de Beneficência 医院的骨髓移植服务。样本包括多发性骨髓瘤 (MM) (58.6%)、淋巴瘤 (29.9%) 和其他肿瘤 (11.5%) 患者。 148 名患者 (94.3%) 实现了 2.0 × 10 6 CD34 细胞/kg 的目标，在大多数情况下 (84.1%) 在单次血浆分离术中，收集的细胞中位数为 9.5 × 10 6 CD34 细胞/kg。没有观察到发热性中性粒细胞减少症发作，但 79 名患者 (50.3%) 需要输注血小板（没有病例归因于出血）。中位植入时间为 11 天。鉴于这些结果，我们建议使用中等剂量的阿糖胞苷与非格司亭联合使用，对于动员造血干细胞 (HSC) 来说是安全有效的。版权所有 © 2023 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular。由 Elsevier España 出版，S.L.U.版权所有。

Autologous hematopoietic stem cell transplantation (Auto-HSCT) is widely used in the treatment of patients with hematological neoplasms. Since these cells circulate in small quantities in the periphery, the use of regimens that promote their mobilization is essential. In this study, we retrospectively evaluated the efficacy and safety of using intermediate doses of cytarabine (1.6 g/m²) + filgrastim (10 mcg/kg/day) in the mobilization of stem cells in 157 patients treated by the Unified Health System at the Hematology and Bone Marrow Transplant Service of the Hospital Real Português de Beneficência, in Recife, Pernambuco. The sample included patients with multiple myeloma (MM) (58.6 %), lymphomas (29.9 %), and other neoplasms (11.5 %). The target of 2.0 × 10 6 CD34+ cells/kg was achieved by 148 (94.3 %) patients, in most cases (84.1 %) in a single apheresis and the median number of cells collected was 9.5 × 10 6 CD34+ cells/kg. No episode of febrile neutropenia was observed, however, 79 patients (50.3 %) required platelet transfusion (no cases attributed to bleeding). The median engraftment time was 11 days. Given these results, we suggest that the use of intermediate doses of cytarabine, combined with filgrastim, is safe and effective in mobilizing hematopoietic stem cells (HSCs).Copyright © 2023 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier España, S.L.U. All rights reserved.