宫颈癌（CC）是发病率最高的妇科肿瘤，其主要原因是高危型人乳头瘤病毒（HPV）持续感染。尽管进行了大量研究，CC 的发病机制仍不清楚。 N6-甲基腺苷 (m6A) 甲基化是 RNA 中最常见的表观遗传修饰形式，与 CC 肿瘤微环境 (TME) 内的细胞增殖、转移、代谢和治疗耐药性密切相关。写入器、读取器和擦除器参与 m6A 修饰，通过调节 RNA 稳定性、核输出、翻译效率和 RNA 降解来影响肿瘤的进展。在这里，我们讨论 m6A 的生物发生、m6A 调节因子的非典型表达、分子相互作用的机制及其在 CC 中的功能。此外，我们阐明了非编码 RNA 的 m6A 修饰。在精准医学的背景下，随着基因组学、蛋白质组学和高通量测序技术的进步，我们总结了m6A在CC临床诊断和治疗中的应用。此外，在检测方法、免疫调节、纳米药物开发等方面提出了新的观点，为m6A的进一步研究奠定了基础，并为CC的临床治疗提供了新思路。© 2023。作者。

Cervical cancer (CC) is a gynecological neoplasm with the highest incidence rate, primarily attributed to the persistent infection of high-risk Human papillomavirus (HPV). Despite extensive research, the pathogenesis of CC remains unclear. N6-methyladenosine (m6A) methylation, the most prevalent form of epigenetic modification in RNA, is intricately linked to cell proliferation, metastasis, metabolism, and therapeutic resistance within the tumor microenvironment (TME) of CC. The involvement of the writer, reader, and eraser in m6A modification impacts the advancement of tumors through the regulation of RNA stability, nuclear export, translation efficiency, and RNA degradation. Here, we discuss the biogenesis of m6A, the atypical expressions of m6A regulators, the mechanisms of molecular interactions, and their functions in CC. Furthermore, we elucidate m6A modification of non-coding RNA. In the context of precision medicine, and with the advancements of genomics, proteomics, and high-throughput sequencing technologies, we summarize the application of m6A in the clinical diagnosis and treatment of CC. Additionally, new perspectives on detection methods, immune regulation, and nano-drug development are presented, which lay the foundation for further research of m6A and provide new ideas for the clinical treatment of CC.© 2023. The Author(s).