肝细胞癌（HCC）是一种高度异质性的癌症，需要更有效的预后标志物。乳酸已被证明是一种重要的代谢产物，参与癌症的发生、转移和肿瘤微环境，影响患者的预后。乳酸代谢调节剂（LAMR）在 HCC 中的作用仍不清楚。在本研究中，我们分析了 HCC 中 LAMR（来自分子特征数据库的包含乳酸的基因列表）的状态，并根据这些 LAMR 进行共识聚类。 B 簇显示出较高的免疫细胞浸润、较高的 TME 评分和较差的预后。我们进一步利用两个簇之间的LASSO和COX回归分析构建了基于DEG的风险评分，可以有效预测TCGA-LIHC患者的预后。 GSE14520 队列证实了这一结果。我们还检查了风险评分与临床特征、基因突变、药物敏感性、免疫检查点抑制剂（ICIs）和免疫治疗的相关性。总之，我们的研究结果将有助于进一步了解部分乳酸代谢相关基因在 HCC 中的作用，并提出新的风险评分来预测预后。© 2023。作者。

Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer, and more effective prognostic markers are needed. Lactic acid has been proved to be an important metabolite involved in cancer development, metastasis, and the tumor microenvironment, affecting the prognosis of patients. The role of lactic acid metabolism regulators (LAMRs) in HCC is still unclear. In this study, we analyzed the status of LAMRs, a gene list containing lactate from Molecular Signatures database, in HCC and consensus clustering was performed based on these LAMRs. Cluster B showed higher infiltrations of immune cells, higher TME scores, and a poorer prognosis. We further constructed a risk score based on DEGs using LASSO and COX regression analysis between two clusters, which could effectively predict the prognosis of TCGA-LIHC patients. The GSE14520 cohort confirmed the result. We also examined the correlation of risk scores with clinical characteristics, genetic mutations, drug sensitivity, immune checkpoint inhibitors(ICIs), and immunotherapy. In conclusion, our findings will facilitate a further understanding of the role of partial lactate metabolism related genes in HCC and suggest a new risk score to predict prognosis.© 2023. The Author(s).