研究动态
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罕见但临床重要的唾液腺型肺肿瘤:综述。

Rare but clinically important salivary gland-type tumor of the lung: A review.

发表日期:2023 Nov 10
作者: Shinkichi Takamori, Yasushi Yatabe, Atsushi Osoegawa, Keiju Aokage, Hiroshige Yoshioka, Tomohiro Miyoshi, Takahiro Mimae, Makoto Endo, Aritoshi Hattori, Masaya Yotsukura, Tetsuya Isaka, Mitsuhiro Isaka, Tomohiro Maniwa, Ryu Nakajima, Shun-Ichi Watanabe
来源: MEDICINE & SCIENCE IN SPORTS & EXERCISE

摘要:

肺部唾液腺型肿瘤 (SGT) 起源于气管支气管树的支气管腺,于 20 世纪 50 年代首次被发现。 SGT 占所有肺部肿瘤的比例不到 1%,据报道通常预后良好。粘液表皮样癌 (MEC) 和腺样囊性癌 (ACC) 是两种最常见的亚型,占所有 SGT 的 90% 以上。据报道,SGT 患者的 5 年生存率为 63.4%。由于此类肿瘤发生在主支气管,SGT 患者通常会出现支气管阻塞的症状,包括呼吸困难、气短、喘息和咳嗽;因此,肿瘤通常在早期就被识别出来。大多数患者接受肺叶切除术和全肺切除术,但通常需要支气管成形术或气管成形术来保留呼吸功能。鉴于已有 MEC 患者淋巴结切除术的临床获益报道,建议在 SGT 手术切除中进行淋巴结切除术。对于晚期肿瘤,由于临床病理特征不同,应根据亚型考虑适当的治疗。 MEC(而非 ACC)不太可能接受放射治疗,因为其反应率较低。尽管多年来研究人员从 SGT 的研究中学到了很多东西,但 SGT 的诊断和治疗对于胸外科医生来说仍然是一个复杂且具有挑战性的问题。在本文中,我们回顾了SGT的诊断、预后和治疗(手术、化疗和放疗),主要关注MEC和ACC。我们还总结了文献中有关 ACC 辅助和根治性放射治疗的报告。© 作者 2023。由牛津大学出版社出版。版权所有。如需权限,请发送电子邮件至:journals.permissions@oup.com。
Salivary gland-type tumor (SGT) of the lung, which arises from the bronchial glands of the tracheobronchial tree, was first recognized in the 1950s. SGT represents less than 1% of all lung tumors and is generally reported to have a good prognosis. Mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) are the two most common subtypes, comprising more than 90% of all SGTs. The reported 5-year survival rate of patients with SGT is 63.4%. Because this type of tumor develops in major bronchi, patients with SGT commonly present with symptoms of bronchial obstruction, including dyspnea, shortness of breath, wheezing, and coughing; thus, the tumor is usually identified at an early stage. Most patients are treated by lobectomy and pneumonectomy, but bronchoplasty or tracheoplasty is often needed to preserve respiratory function. Lymphadenectomy in the surgical resection of SGT is recommended, given that clinical benefit from lymphadenectomy has been reported in patients with MEC. For advanced tumors, appropriate therapy should be considered according to the subtype because of the varying clinicopathologic features. MEC, but not ACC, is less likely to be treated with radiation therapy because of its low response rate. Although previous researchers have learned much from studying SGT over the years, the diagnosis and treatment of SGT remains a complex and challenging problem for thoracic surgeons. In this article, we review the diagnosis, prognosis, and treatment (surgery, chemotherapy, and radiotherapy) of SGT, mainly focusing on MEC and ACC. We also summarize reports of adjuvant and definitive radiation therapy for ACC in the literature.© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.