AMP 激活蛋白激酶 (AMPK) 是一种维持细胞能量稳态的能量状态传感器。 AMPK 的激活增强增殖物激活受体 γ 共激活因子 1α (PGC1-α) 的表达，随后激活线粒体转录因子 A (TFAM) 以调节线粒体氧化呼吸功能。 AMPK、p-AMPK、PGC-1α 和 TFAM 的可能功能及其在星形细胞瘤中的相互作用尚不清楚。在此，评估了星形细胞瘤中 AMPK、p-AMPK、PGC-1α 和 TFAM 表达水平的水平、临床病理特征和预后潜力。结果显示星形细胞瘤中 AMPK、p-AMPK、PGC-1α 和 TFAM 表达水平升高。在星形细胞瘤患者中观察到 AMPK、p-AMPK、PGC-1α 和 TFAM 表达之间存在很强的相关性。分析表明AMPK、p-AMPK、PGC-1α和TFAM的水平与生存相关。 AMPK 水平、肿瘤分级和年龄是预测星形细胞瘤患者预后不良的独立预后因素。总之，这些结果表明，这 4 个靶点可能在人类星形细胞瘤的进展和预后中发挥至关重要的作用，并且 AMPK 可能代表一个潜在的治疗靶点。© 作者 2023。由牛津大学出版社代表美国协会出版神经病理学家有限公司保留所有权利。如需权限，请发送电子邮件至：journals.permissions@oup.com。

AMP-activated protein kinase (AMPK) is a sensor of energy status that maintains cellular energy homeostasis. Activation of AMPK enhances the expression of proliferator-activated receptor γ coactivator 1α (PGC1-α) and subsequently activates mitochondrial transcription factor A (TFAM) to regulate mitochondrial oxidative respiratory function. The possible functions of AMPK, p-AMPK, PGC-1α, and TFAM and their interactions in astrocytomas are not known. Here, the levels, clinicopathological characteristics, and prognostic potential of AMPK, p-AMPK, PGC-1α, and TFAM expression levels in astrocytomas were evaluated. The results showed that levels of AMPK, p-AMPK, PGC-1α, and TFAM expression was increased in astrocytomas. Strong correlations were observed between AMPK, p-AMPK, PGC-1α, and TFAM expression in patients with astrocytomas. The analysis indicated that the levels of AMPK, p-AMPK, PGC-1α, and TFAM were associated with the survival. AMPK levels, tumor grade, and age were independent prognostic factors predicting poor outcomes in patients with astrocytoma. Together, these results indicate that these 4 targets may play a crucial role in the progression and prognosis of human astrocytomas and that AMPK may represent a potential therapeutic target.© The Author(s) 2023. Published by Oxford University Press on behalf of American Association of Neuropathologists, Inc. All rights reserved. For permissions, please email: journals.permissions@oup.com.