我们在此报告一例弥漫性大 B 细胞淋巴瘤 (DLBCL) 病例，涉及多发性肾脏和骨骼浸润，表现为巨细胞动脉炎样 (GCA) 样表现。一个月前，该患者出现左侧颞部头痛、下颌跛行和肾功能衰竭。根据肾活检，该患者被诊断为 DLBCL。经利妥昔单抗、环磷酰胺、阿霉素、长春新碱、泼尼松（R-CHOP）联合鞘内注射甲氨蝶呤/阿糖胞苷/泼尼松联合利妥昔单抗、大剂量甲氨蝶呤、阿糖胞苷（R-MA）化疗后，患者临床表现改善，完全缓解。实现了。 DLBCL 很少但偶尔会出现类似 GCA 的表现或多发性肾脏和骨骼浸润，这凸显了及时、积极的联合化疗的必要性。

We herein report a case of diffuse large B-cell lymphoma (DLBCL) involving multiple renal and bone infiltrations presenting with giant cell arteritis-like (GCA)-like manifestations. One month prior, the present patient had left-sided temporal headache, jaw claudication, and renal failure. The patient was diagnosed with DLBCL based on a renal biopsy. After rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) plus intrathecal methotrexate/cytarabine/prednisone and rituximab, high-dose methotrexate, and cytarabine (R-MA) chemotherapy, the patient's clinical manifestations improved, and complete remission was achieved. DLBCL rarely but occasionally presents with GCA-like manifestations or multiple renal and bone infiltrations, highlighting the need for prompt and aggressive combination chemotherapy.