脑肿瘤患者心血管疾病（CVD）标准化死亡率升高可能是由于CVD发病率和心血管危险因素的差异所致。我们将原发性恶性或非恶性脑肿瘤患者的 CVD 风险与匹配的一般人群队列进行了比较，并考虑了其他合并症。使用来自威尔士（英国）安全匿名信息链接 (SAIL) 数据库的数据，我们在初级保健数据库中确定了 2000 年至 2014 年癌症登记处首次诊断出恶性或非恶性脑肿瘤的所有年龄≥18 岁的成年人，以及匹配的队列（病例与对照比率 1:5）来自没有任何癌症诊断的普通人群的年龄、性别和初级保健提供者。结果包括致命和非致命的主要血管事件（中风、缺血性心脏病、主动脉和外周血管疾病）和静脉血栓栓塞（VTE）。我们使用针对临床风险因素进行调整的多变量 Cox 模型来比较风险，并按肿瘤行为（恶性或非恶性）和随访期进行分层。在 2017 和 2017 年间，分别有 2869 人和 3931 人被诊断出患有恶性或非恶性脑肿瘤。 2000 年和 2014 年在威尔士。他们与 33,785 名对照进行匹配。在肿瘤诊断的第一年内，恶性肿瘤与较高的 VTE 风险（风险比 [HR] 21.58，95% 置信区间 16.12-28.88）和中风（HR 3.32、2.44-4.53）相关。第一年后，VTE（HR 2.20、1.52-3.18）和中风（HR 1.45、1.00-2.10）的风险仍然高于对照组。与非恶性肿瘤患者相比，非恶性肿瘤患者在诊断第一年内发生 VTE（HR 3.72、2.73-5.06）、中风（HR 4.06、3.35-4.93）以及主动脉和外周动脉疾病（HR 2.09、1.26-3.48）的风险更高CVD 和 VTE 风险升高表明，降低风险可能是改善脑肿瘤患者生活质量和生存的一种策略。© 2023。作者。

Elevated standardised mortality ratio of cardiovascular diseases (CVD) in patients with brain tumours may result from differences in the CVD incidences and cardiovascular risk factors. We compared the risk of CVD among patients with a primary malignant or non-malignant brain tumour to a matched general population cohort, accounting for other co-morbidities.Using data from the Secured Anonymised Information Linkage (SAIL) Databank in Wales (United Kingdom), we identified all adults aged ≥ 18 years in the primary care database with first diagnosis of malignant or non-malignant brain tumour identified in the cancer registry in 2000-2014 and a matched cohort (case-to-control ratio 1:5) by age, sex and primary care provider from the general population without any cancer diagnosis. Outcomes included fatal and non-fatal major vascular events (stroke, ischaemic heart disease, aortic and peripheral vascular diseases) and venous thromboembolism (VTE). We used multivariable Cox models adjusted for clinical risk factors to compare risks, stratified by tumour behaviour (malignant or non-malignant) and follow-up period.There were 2869 and 3931 people diagnosed with malignant or non-malignant brain tumours, respectively, between 2000 and 2014 in Wales. They were matched to 33,785 controls. Within the first year of tumour diagnosis, malignant tumour was associated with a higher risk of VTE (hazard ratio [HR] 21.58, 95% confidence interval 16.12-28.88) and stroke (HR 3.32, 2.44-4.53). After the first year, the risks of VTE (HR 2.20, 1.52-3.18) and stroke (HR 1.45, 1.00-2.10) remained higher than controls. Patients with non-malignant tumours had higher risks of VTE (HR 3.72, 2.73-5.06), stroke (HR 4.06, 3.35-4.93) and aortic and peripheral arterial disease (HR 2.09, 1.26-3.48) within the first year of diagnosis compared with their controls.The elevated CVD and VTE risks suggested risk reduction may be a strategy to improve life quality and survival in people with a brain tumour.© 2023. The Author(s).