研究动态
Articles below are published ahead of final publication in an issue. Please cite articles in the following format: authors, (year), title, journal, DOI.

罗兰迪克周围区域脑转​​移瘤的治疗结果:手术与立体定向放射外科手术的比较。

Treatment Outcome of the Brain Metastases in Peri-Rolandic Area: Comparison Between Surgery and Stereotactic Radiosurgery.

发表日期:2023 Oct
作者: Jun Hyeok Jung, Kawngwoo Park, Eun Young Kim, Chan-Jong Yoo, Gi-Taek Yee, Woo-Kyung Kim, Dong-Won Shin
来源: MEDICINE & SCIENCE IN SPORTS & EXERCISE

摘要:

罗兰周围区的脑转移至关重要,因为它直接影响癌症患者的生活质量。与其他脑转移瘤一样,罗兰迪克周围脑转移瘤也考虑手术或立体定向放射外科手术 (SRS)。然而,对于这种肿瘤,每种治疗方式对功能结果的益处尚未明确定义。本研究的目的是比较每种治疗的功能过程,并为患者的生活质量提出有效的治疗方法。回顾性纳入52例因增强MRI证实的脑转移而接受SRS或手术的患者。使用 Kaplan-Meier 方法、单变量、多变量分析和 Cox 比例风险回归估计总生存期 (OS)、无进展生存期 (PFS) 和功能结果。我们研究人群的中位 OS 和 PFS 分别为 13.3 个月和 8.9 个月。治疗方式不是 OS 和 PFS 的重要因素。颅外全身癌症进展是这两个参数的重要因素(OS 的 p=0.030,PFS 的 p=0.040)。手术组的中位症状改善时间(与术前状态相比术后至少改善 1 级)时间显着短于 SRS 组(10.5 天 vs. 37.5 天,p=0.034)。脑转移手术可有助于患者余生的积极生活质量。版权所有 © 2023 韩国脑肿瘤学会、韩国神经肿瘤学会和韩国儿科神经肿瘤学会。
Brain metastases of peri-Rolandic area is crucial as it directly impacts the quality of life for cancer patients. Surgery or stereotactic radiosurgery (SRS) is considered for peri-Rolandic brain metastases as for other brain metastases. However, the benefit of each treatment modality on functional outcome has not been clearly defined for this tumor. The purpose of this study is to compare the functional course of each treatment and to suggest an effective treatment for patients' quality of life.Fifty-two patients who had undergone SRS or surgery for brain metastasis confirmed by enhanced MRI were enrolled retrospectively. Overall survival (OS), progression free survival (PFS), and functional outcomes were estimated using the Kaplan-Meier method, univariate, multivariate analysis, and Cox proportional hazards regression.Median OS and PFS were 13.3 months and 8.9 months in our study population. Treatment modalities were not significant factors for OS and PFS. Extracranial systemic cancer progression was significant factor for both parameters (p=0.030 for OS and p=0.040 for PFS). Median symptom improvement (improvement of at least 1 grade after surgery compared to preoperative state) time was significantly shorter in surgery group than in the SRS group (10.5 days vs. 37.5 days, p=0.034).Surgery for brain metastases can contribute to a positive quality of life for the remaining duration of the patient's life.Copyright © 2023 The Korean Brain Tumor Society, The Korean Society for Neuro-Oncology, and The Korean Society for Pediatric Neuro-Oncology.