研究动态
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成人室管膜瘤广泛软脑膜扩散:病例报告和文献综述。

Extensive Leptomeningeal Spreading of Ependymoma in an Adult: Case Report and Literature Review.

发表日期:2023 Oct
作者: Joonseo Kang, Kwon Woo Lee, Yeongu Chung, Yusam Won, Je Beom Hong
来源: Brain Structure & Function

摘要:

室管膜瘤是一种罕见的成人肿瘤,起源于中枢神经系统的室管膜细胞,主要发生在脑室或脊髓中央管。在本文中,我们报道了一名 39 岁男性患者的室管膜瘤软脑膜广泛种植病例,该患者是在头部外伤后偶然发现的。 MRI 显示弥漫性软脑膜浸润性病变以及双侧多发性脑沟、基底池、桥小脑角、小脑叶。它还显示出沿整个脊髓的多结节增强 T1 低 T2 高信号强度病变。右颞部病灶肿瘤活检后,病理诊断为经典室管膜瘤(WHO 2级)。患者已接受放射治疗和化疗,目前术后两年病情稳定。该报告建议,在考虑颅内和椎管内广泛病变的鉴别诊断时,还应考虑室管膜瘤。版权所有 © 2023 韩国脑肿瘤学会、韩国神经肿瘤学会和韩国儿科神经学会-肿瘤学。
Ependymoma is a rare adult tumor that originates from ependymal cells of the central nervous system, primarily occurring in the cerebral ventricles or the central canal of the spinal cord. In this paper, we report a case of extensive leptomeningeal seeding of ependymoma of a 39-year-old male patient, in whom the tumor was found incidentally after head trauma. The MRI exhibited diffuse leptomeningeal infiltrative lesions along with bilateral multiple cerebral sulci, basal cisterns, cerebellopontine angle, cerebellar folia. It also showed multinodular enhancing T1 low T2 high signal intensity lesions along the whole spinal cord. After the tumor biopsy at right temporal lesion, pathologic diagnosis was classic ependymoma (WHO grade 2). The patient has undergone radiation therapy and chemotherapy, and is currently maintaining a stable condition two years after surgery. This report suggests that when considering the differential diagnosis of extensive lesions both in the intracranial and intraspinal space, ependymoma should also be considered.Copyright © 2023 The Korean Brain Tumor Society, The Korean Society for Neuro-Oncology, and The Korean Society for Pediatric Neuro-Oncology.