透明质酸 (HA) 是细胞外基质的主要成分，为细胞提供必要的机械支架，同时介导组织稳态所需的重要生化信号。许多实体瘤的特点是HA代谢失调，导致癌组织中HA水平升高。 HA 与多种细胞表面受体相互作用，例如 CD44 和 RHAMM，从而共同调节癌症发生和进展中的重要信号通路。在这篇综述中，我们描述了控制 HA 代谢的酶及其细胞内效应子，强调了它们对癌症化疗耐药性的影响。我们还将探讨基于 HA 的治疗的当前和未来前景，强调该领域的机遇和挑战。本文受版权保护。版权所有。

Hyaluronic acid (HA) is a major component of the extracellular matrix, providing essential mechanical scaffolding for cells and, at the same time, mediating essential biochemical signals required for tissue homeostasis. Many solid tumors are characterized by dysregulated HA metabolism, resulting in increased HA levels in cancer tissue. HA interacts with several cell surface receptors, such as CD44 and RHAMM, thus co-regulating important signaling pathways in cancer development and progression. In this review, we describe the enzymes controlling HA metabolism and its intracellular effectors emphasizing their impact in cancer chemotherapy resistance. We will also explore the current and future prospects of HA-based therapy, highlighting the opportunities and challenges in the field.This article is protected by copyright. All rights reserved.