研究按年龄组划分的全球疾病负担和特定国家的阴茎癌发病率趋势，并调查其与多个因素的关联。检索了全球癌症观察数据库中的阴茎癌发病率。 10 年癌症发病率来自五大洲癌症发病率加上。特定国家的数据是从世界卫生组织全球卫生观察站和全球疾病负担数据库中提取的，用于进行风险因素分析。阴茎癌发病率采用年龄标准化率表示。通过线性回归检查其与各种因素的关联，同时使用连接点回归估计发病率趋势，并以不同年龄组的平均年百分比变化（95％置信区间）表示。 2020年估计有36,068例新发阴茎癌病例。阴茎癌的疾病负担存在相当大的地理差异，南美洲的发病率最高。总体而言，饮酒、艾滋病毒感染和不安全性行为与较高的阴茎癌发病率呈正相关，而包皮环切术被发现是一个保护因素。阴茎癌的发病率总体呈混合趋势，但在年轻男性中呈上升趋势。与饮酒、艾滋病毒感染、不安全性行为和包皮环切相关的阴茎癌负担存在全球差异。年轻人中阴茎癌发病率的上升令人担忧，呼吁早期发现和预防干预。本文受版权保护。版权所有。

To examine the global disease burden and country-specific trends of penile cancer incidence by age group, and investigate its associations with several factors.Global Cancer Observatory database was retrieved for the penile cancer incidence. The 10-year cancer incidence rates were collected from the Cancer Incidence in Five Continents Plus. The country-specific data were extracted from the WHO Global Health Observatory and Global Burden of Disease databases for conducting risk factors analysis. The penile cancer incidence was presented using age-standardized rates. Its associations with various factors were examined by linear regression, while the incidence trend was estimated using joinpoint regression and presented as average annual percentage change with 95% confidence intervals in different age groups.There were an estimated 36,068 new cases of penile cancer in 2020. There was a considerable geographical disparity in the disease burden of penile cancer, with South America reporting the highest incidence. Overall, alcohol drinking, HIV infection, and unsafe sex were positively associated with a higher penile cancer incidence, while circumcision was found to be a protective factor. There has been a mixed trend in penile cancer incidence overall, but an increasing trend was found among younger males.There was a global variation in the penile cancer burden associated with prevalence of alcohol drinking, HIV infection, unsafe sex, and circumcision. The increasing penile cancer incidence in the younger population is worrying and calls for early detection and preventive interventions.This article is protected by copyright. All rights reserved.