长效新冠肺炎是一种新兴的公共卫生负担，被定义为一种综合征，其常见症状包括疲劳、呼吸短促、认知功能障碍以及其他影响日常生活、波动或复发的症状，且在一年内至少出现两个月。有可能或确诊的 SARS CoV-2 感染史的患者；通常是从发病后三个月开始，并且不能用其他诊断来解释。长期COVID-19的实际患病率尚不清楚，但据信，欧洲在大流行期间可能有超过1700万患者患有该病。目前，对该综合征的病理生理学了解有限，多种假设被提议。我们的文献综述显示，与对照组相比，报告了 COVID-19 患者尸检大脑组织样本中 tau 沉积物的研究，并且体外人脑类器官模型显示 tau 蛋白响应 SARS-CoV 的异常磷酸化-2感染。 Tau 病是一组以 tau 沉积物为显着特征的神经退行性疾病，根据大脑受累的解剖区域可以表现出不同的症状，并且已被证明也会影响周围神经系统，甚至在大鼠模型研究中也得到了解释。长COVID有超过203种症状，主要症状是疲劳、呼吸困难和认知功能障碍，tau蛋白病引起的中枢神经系统和周围神经系统功能障碍可以解释这些症状。迄今为止，尚无研究揭示长期新冠病毒的病理生理学。根据我们的文献综述，异常的 tau 磷酸化是一个有前景的假设，可以在未来的研究中进行探索。 tau蛋白病的治疗方法具有多维性，包括在溶酶体的帮助下通过自噬过程靶向翻译后修饰、tau蛋白聚集和tau蛋白清除，这可能是开发长期新冠治疗干预措施的潜在目标。此外，未来的研究可以尝试寻找脑脊液中的 tau 蛋白，并将其用作长期新冠病毒的生物标志物。版权所有 © 2023 Marwaha。

Long COVID is an emerging public health burden and has been defined as a syndrome with common symptoms of fatigue, shortness of breath, cognitive dysfunction, and others impacting day-to-day life, fluctuating or relapsing over, occurring for at least two months in patients with a history of probable or confirmed SARS CoV-2 infection; usually three months from the onset of illness and cannot be explained by an alternate diagnosis. The actual prevalence of long-term COVID-19 is unknown, but it is believed that more than 17 million patients in Europe may have suffered from it during pandemic.Currently, there is limited understanding of the pathophysiology of this syndrome, and multiple hypotheses have been proposed. Our literature review has shown studies reporting tau deposits in tissue samples of the brain from autopsies of COVID-19 patients compared to the control group, and the in-vitro human brain organoid model has shown aberrant phosphorylation of tau protein in response to SARS-CoV-2 infection. Tauopathies, a group of neurodegenerative disorders with the salient features of tau deposits, can manifest different symptoms based on the anatomical region of brain involvement and have been shown to affect the peripheral nervous system as well and explained even in rat model studies. Long COVID has more than 203 symptoms, with predominant symptoms of fatigue, dyspnea, and cognitive dysfunction, which tauopathy-induced CNS and peripheral nervous system dysfunction can explain. There have been no studies up till now to reveal the pathophysiology of long COVID. Based on our literature review, aberrant tau phosphorylation is a promising hypothesis that can be explored in future studies. Therapeutic approaches for tauopathies have multidimensional aspects, including targeting post-translational modifications, tau aggregation, and tau clearance through the autophagy process with the help of lysosomes, which can be potential targets for developing therapeutic interventions for the long COVID. In addition, future studies can attempt to find the tau proteins in CSF and use those as biomarkers for the long COVID.Copyright © 2023 Marwaha.