除了止血和凝血作用外，多年的研究证明血小板参与肿瘤进展的全过程，包括肿瘤的侵袭、内渗、外渗等。这意味着血小板的这种特性可以用于抗肿瘤治疗。然而，传统的血小板抗肿瘤药物往往因缺乏靶向性而导致自体血小板损伤，从而产生严重的副作用。因此，研究人员通过靶向血小板或血小板膜涂层，设计了多种基于血小板的抗肿瘤药物递送系统。药物递送系统具有特殊的响应模式，这对于纳米颗粒的设计至关重要。这些模式增强了靶向性并提高了抗肿瘤效果。在此，我们回顾了血小板与肿瘤之间相互作用领域的最新发现以及基于血小板的抗肿瘤纳米颗粒的进展。© 2023 Yang et al.

In addition to hemostasis and coagulation, years of studies have proved that platelets are involved in the whole process of tumor progression, including tumor invasion, intravasation, extravasation, and so on. It means that this property of platelets can be used in anti-tumor therapy. However, traditional platelet-based antitumor drugs often cause autologous platelet damage due to lack of targeting, resulting in serious side effects. Therefore, the researchers designed a variety of anti-tumor drug delivery systems based on platelets by targeting platelets or platelet membrane coating. The drug delivery systems have special response modes, which is crucial in the design of nanoparticles. These modes enhance the targeting and improve the anti-tumor effect. Here, we present a review of recent discoveries in the field of the crosstalk between platelets and tumors and the progress of platelet-based anti-tumor nanoparticles.© 2023 Yang et al.