伊拉克库尔德斯坦地区瑞香的甲醇提取物是抗氧化剂、抗菌剂和抗癌剂的有效来源，用于合成新型生物活性聚乙烯吡咯烷酮纳米纤维。
Methanol extract of Iraqi Kurdistan Region Daphne mucronata as a potent source of antioxidant, antimicrobial, and anticancer agents for the synthesis of novel and bioactive polyvinylpyrrolidone nanofibers.
发表日期：2023
作者：
Khursheed Muzammil, Mazin Hadi Kzar, Faraj Mohammed, Zahraa Ibrahim Mohammed, Sarah A Hamood, Talib Kh Hussein, Saheb Jubeir Hanoon, Maytham T Qasim, Ahmed Hussien Alawadi, Ali Alsalamy
来源：
ANTIOXIDANTS & REDOX SIGNALING
摘要：
在本研究中，由于纳米纤维在生物和医学领域（包括食品包装、酶稳定和伤口敷料）中的大量应用和发展，制备了伊拉克库尔德斯坦地区瑞香的水、乙醇、甲醇和己烷提取物。在提取物的初步评估中，对 DPPH 的抗氧化特性、对 3 种革兰氏阳性细菌、3 种革兰氏阴性细菌、3 种水生和人类常见细菌以及 3 种真菌的抗菌特性以及抗癌特性进行了针对乳腺癌细胞的特性研究。结果证明，甲醇提取物具有最高的抗菌、抗真菌、抗氧化和抗癌特性。使用GC/MS对所制备的甲醇提取物进行成分鉴定后，制备出含有瑞香甲醇提取物的聚乙烯吡咯烷酮纳米纤维。利用 FTIR、TGA、BET、SEM、弯曲强度、压缩强度和亲水性对所制备的纳米纤维的结构和特性进行了确认和测定。含有 D. mucronata 甲醇提取物的合成聚乙烯吡咯烷酮纳米纤维对 D. mucronata 甲醇提取物中研究的菌株具有抗菌特性。比较了含有 D. mucronata 甲醇提取物的合成聚乙烯吡咯烷酮纳米纤维的抗菌性能。结果表明，含有 D. mucronata 甲醇提取物的合成聚乙烯吡咯烷酮纳米纤维具有引入生物活性天然合成纳米颗粒的潜力。版权所有 © 2023 Muzammil, Kzar, Mohammed, Mohammed, Hamood, Hussein, Hanoon, Qasim, Hussien Alawadi and Alsalamy。
In this study, aqueous, ethanol, methanol, and hexane extracts from Iraqi Kurdistan Region Daphne mucronata were prepared due to the numerous applications and development of nanofibers in biological and medical fields, including food packaging, enzyme stabilization, and wound dressing. In the initial evaluation of the extracts, the antioxidant properties against DPPH, antimicrobial properties against 3-gram-positive bacterial species, 3-gram negative bacterial species, 3-common bacterial species between aquatic and human, and 3-fungal species, and anticancer properties against breast cancer cells were performed. The results proved that the methanol extract has the highest antimicrobial, antifungal, antioxidant, and anticancer properties. After identifying the compounds of prepared methanol extract using GC/MS, polyvinylpyrrolidone nanofibers containing methanol extract of Daphne mucronata were prepared. The structure and characteristics of prepared nanofibers were confirmed and determined using FTIR, TGA, BET, SEM, flexural strength, compressive strength, and hydrophilicity. Synthesized polyvinylpyrrolidone nanofibers containing methanol extract of D. mucronata were subjected to antimicrobial properties on the strains studied in methanol extract of D. mucronata. The antimicrobial properties of synthesized polyvinylpyrrolidone nanofibers containing methanol extract of D. mucronata were compared. The results showed that synthesized polyvinylpyrrolidone nanofibers containing methanol extract of D. mucronata have the potential to introduction bioactive natural synthesis nanoparticles.Copyright © 2023 Muzammil, Kzar, Mohammed, Mohammed, Hamood, Hussein, Hanoon, Qasim, Hussien Alawadi and Alsalamy.