卟啉由于其优异的性能，在许多前沿领域得到了广泛的探索和应用，并取得了许多令人鼓舞的成果。作为卟啉的重要衍生物，卟啉基两亲物（PBA）不仅保持了卟啉的先进性质（催化、成像和能量转移），而且还具有在水溶液中的自组装和封装能力。因此，PBA及其自组装体在诊断和治疗体内肿瘤和炎症病变方面具有重要作用，但不仅限于这些。在本文中，我们介绍了PBA的研究进展，包括其组成、结构设计策略以及在肿瘤和炎症病变诊断和治疗中的性能。在此基础上，还提出了合成PBA在应用过程中的缺陷以及克服这些限制的可能有效策略。最后，根据我们的知识更新了对 PBA 探索的观点。我们希望这篇综述能为来自不同领域的研究人员带来有关 PBA 的见解。

Porphyrins have been vastly explored and applied in many cutting-edge fields with plenty of encouraging achievements because of their excellent properties. As important derivatives of porphyrins, porphyrin-based amphiphiles (PBAs) not only maintain the advanced properties of porphyrins (catalysis, imaging, and energy transfer) but also possess self-assembly and encapsulation capability in aqueous solution. Accordingly, PBAs and their self-assembles have had important roles in diagnosing and treating tumors and inflammation lesions in vivo, but not limited to these. In this article, we introduce the research progress of PBAs, including their constitution, structure design strategies, and performances in tumor and inflammation lesion diagnosis and treatments. On that basis, the defects of synthesized PBAs during their application and the possible effective strategies to overcome the limitations are also proposed. Finally, perspectives on PBAs exploration are updated based on our knowledge. We hope this review will bring researchers from various domains insights about PBAs.