代谢综合征 (MetS) 的定义是存在三种以上的代谢失调，例如高脂血症、高胰岛素血症、向心性肥胖和高血压，它与心血管疾病、糖尿病和各种癌症（包括浸润性乳腺癌 (IBC)）的风险增加有关。 ）。 MetS 是否是乳腺导管原位癌 (DCIS)（IBC 的非必然前兆）的危险因素仍不清楚。在英国入组时，共有 198,748 名 40-69 岁女性，无 DCIS 和 IBC生物银行，包括在本研究中。使用多变量调整的 Cox 比例风险模型来估计 MetS 与 DCIS 之间的关联。在平均 11.4 年的随访期间，总共确定了 1,251 例 DCIS 病例。 MetS 与总体 DCIS 风险或绝经状态之间没有关联。对 MetS 各个组成部分的分析显示，中心性肥胖（腰围≥88cm）与绝经后女性 DCIS 风险增加之间存在关联。在这项前瞻性研究中，我们发现 MetS 与 DCIS 风险之间没有关联。研究结果不支持 MetS 之间的关联。以及乳腺癌的前兆。

Metabolic syndrome (MetS), defined by the presence of three of more metabolic dysregulations such as hyperlipidemia, hyperinsulinemia, central obesity, and hypertension, has been associated with increased risk of cardiovascular disease, diabetes, and various cancers, including invasive breast cancer (IBC). Whether MetS is a risk factor for ductal carcinoma in situ of the breast (DCIS), a non-obligate precursor of IBC, remains unknown.A total of 198,748 women aged 40-69 years, DCIS- and IBC-free at enrolment in UK Biobank, were included in the present study. Multivariable-adjusted Cox proportional hazards models were used to estimate the association between MetS and DCIS.A total of 1,251 DCIS cases were ascertained during an average follow-up of 11.4 years. There was no association between MetS and the risk of DCIS overall, or by menopausal status. Analysis of individual components of MetS showed an association between central obesity (waist circumference ≥88cm) and increased DCIS risk in postmenopausal women.In this prospective study we found no association between MetS and DCIS risk.The study findings do not support an association between MetS and this breast cancer precursor.