GrimAge 加速 (GAA) 是一种代表生理衰老的表观遗传标记，与包括癌症和心血管疾病在内的年龄相关疾病相关。然而，GAA 与肌肉质量和功能之间的关联尚不清楚。我们在考试年 (Y) 15 (2000-01) 估计了来自年轻人冠状动脉风险发展 (CARDIA) 研究的 1118 名黑人和白人参与者的 GAA 测量值和 20 (2005-06)。在第 25 年（2010-11）访视时使用 CT 扫描测量腹部肌肉成分。我们使用多元回归模型来检查 GAA 估计值与肌肉成像测量值的关联。在 CARDIA 研究中，GAA 每升高一年，肌间脂肪组织平均升高 1.1% (95% CI 0.6%, 1.5%) [IMAT] ] 腹部肌肉的体积。 GAA 每增加一年，与平均 -0.089 亨斯菲尔德单位 (HU) (95% CI -0.146, -0.032) 较低的瘦肌肉衰减和平均 -0.049 HU (95% CI -0.092, -0.007) 较低的 IMAT 相关腹部肌肉的衰减。分层分析表明，GAA 与女性中较高的腹部肌肉 IMAT 体积相关性更强，并且仅与白人参与者的较低瘦肌肉衰减显着相关。在中年人群中，较高的 GAA 与较高的腹部肌肉 IMAT 体积和较低的瘦肌肉衰减相关。 © 作者 2023。由牛津大学出版社代表美国老年学协会出版。版权所有。如需权限，请发送电子邮件至：journals.permissions@oup.com。

GrimAge acceleration (GAA), an epigenetic marker that represents physiologic aging, is associated with age-related diseases including cancer and cardiovascular diseases. However, the associations between GAA and muscle mass and function are unknown.We estimated measures of GAA in 1118 Black and White participants from the Coronary Artery Risk Development in Young Adults (CARDIA) Study at exam years (Y) 15 (2000-01) and 20 (2005-06). Abdominal muscle composition was measured using CT scans at the year 25 (2010-11) visit. We used multivariate regression models to examine associations of GAA estimates with muscle imaging measurements.In the CARDIA study, each one-year higher GAA was associated with an average 1.1% (95% CI 0.6%, 1.5%) higher intermuscular adipose tissue [IMAT] volume for abdominal muscles. Each one-year higher GAA was associated with an average -0.089 Hounsfield unit (HU) (95% CI -0.146, -0.032) lower lean muscle attenuation and an average -0.049 HU (95% CI -0.092, -0.007) lower IMAT attenuation for abdominal muscles. Stratified analyses showed that GAA was more strongly associated with higher abdominal muscle IMAT volume in females and significantly associated with lower lean muscle attenuation for White participants only.Higher GAA is associated with higher abdominal muscle IMAT volume and lower lean muscle attenuation in a midlife population.© The Author(s) 2023. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.