鱼腥草。 （H. cordata；三白草科）是一种药食同源植物，在许多亚洲国家都有种植。其主要植物化学成分为挥发油、黄酮类、多糖和生物碱。具有相当可观的临床应用和保健功效。本文对现有文献和专利进行综述，对红花的植物化学、药理活性、安全性和经济植物学应用进行综述，为系统研究红花的药理作用提供参考。利用PubMed、Google Scholar、Web of Science、中国知识网对2023年6月之前发表的有关H. cordata及其活性成分的文献和专利进行全面检索。 。 Cordata不仅可食用和药用，还用于发酵饮料、营养保健品、饲料和化妆品等日常生活的各个方面。 H.cordata的主要植物化学成分是挥发油、黄酮类、有机酸和生物碱。多项体外和体内研究及临床试验发现，H. cordata 提取物具有抗氧化、抗炎、抗肿瘤、抗菌、保肝肾、免疫调节和强效抗病毒作用。这些药理作用的表达机制与血脑屏障、亲脂性、cAMP信号和皮肤通透性有关，包括阻断MAPK信号通路、抑制TNF-α和IL-1β等炎症因子的分泌、激活本文全面综述了H. cordata的传统应用、植物学、化学成分、药理作用和安全性等方面的研究进展，并首次讨论了国内未曾探讨过的经济植物学方面。以前的评论。 H.cordata具有广泛的生物活性物质，其治疗潜力尚未得到充分开发，它可以为许多疾病提供新的无毒途径。这种传统的药用食品植物未来应该受到更多的关注和深入的研究。版权所有 © 2023 Elsevier GmbH。版权所有。

Houttuynia Cordata Thunb. (H. cordata; Saururaceae) is a medicine food homology plant that is grown in many Asian countries. Its main phytochemical constituents are volatile oils, flavonoids, polysaccharides and alkaloids. It has considerable clinical applications and health benefits.This paper reviews the existing literatures and patents, summarizes the phytochemistry, pharmacological activity, safety and economic botanical applications of H. cordata, and provides a reference for systematic study of the pharmacological effects of H. cordata, improvement of quality standards and further development of its medicinal resources.A comprehensive search of literature and patents on H. cordata and its active ingredients published before June 2023 was conducted using PubMed, Google Scholar, Web of Science, and China Knowledge Network.H. cordata is not only edible and medicinal but also used in various aspects of daily life such as fermented beverages, nutraceuticals, feed and cosmetics. The main phytochemical constituents of H. cordata are volatile oils, flavonoids, organic acids and alkaloids. Several in vitro and in vivo studies and clinical trials have found that H. cordata extracts possess antioxidant, anti-inflammatory, antitumor, antibacterial, hepatoprotective and renal, immunomodulatory and potent antiviral effects. The mechanisms of expression of these pharmacological effects are related to the blood-brain barrier, lipophilicity, cAMP signaling and skin permeability, including blocking the MAPK signaling pathway, inhibiting the secretion of inflammatory factors such as TNF-α and IL-1β, and activating the AMPK pathway.This paper provides a comprehensive review of the progress of research on the traditional applications, botany, chemical composition, pharmacological effects and safety of H. cordata and discusses for the first time the economic botanical aspects, which were not explored in the previous reviews. H. cordata has a wide range of bioactive substances whose therapeutic potential has not been fully exploited, and it could provide a new non-toxic approach to many diseases. This traditional medicinal food plant should receive more attention and in-depth research in the future.Copyright © 2023 Elsevier GmbH. All rights reserved.