评估健康的社会决定因素 (SDH) 与眼癌患者的表现和结果之间的关联。查询国家癌症数据库以了解诊断的 T1-T4 N0M0 葡萄膜黑色素瘤、结膜黑色素瘤或视网膜母细胞瘤的原发性临床肿瘤 (cT) 分类2006 年 1 月至 2017 年 12 月之间。皮尔逊卡方分析评估了癌症队列之间 SDH 相关特征的差异。进行了调整优势比 (aOR) 的二元逻辑回归和具有 95% 置信区间 (CI) 的多变量 Cox 比例风险比 (HR)。采用全国代表性样本进行横断面结果：3968 例葡萄膜黑色素瘤病例，352 例结膜黑色素瘤病例，共纳入 480 例视网膜母细胞瘤病例。种族、主要付款人状况、收入四分位数、人口密度、设施位置、Charlson-Deyo 合并症评分、既往恶性肿瘤史、就诊时的 cT 分类、手术治疗、放疗、化疗、30 天再入院和总生存期 (OS) 方面的差异）在癌症中观察到。女性（aOR=0.819，95% CI=0.689-0.973）和最高收入四分位数（aOR=0.691，95% CI=0.525-0.908）在就诊时进行高级 cT 分类的可能性降低。没有保险（aOR=1.736，95% CI=1.159-2.601）和医疗补助主要付款人状态（aOR=1.875，95% CI=1.323-2.656）增加高级 cT 分类的可能性。农村地区的患者（aOR=7.157，95% CI=1.875-27.320）更有可能在初次治疗后 30 天内再次入院。年龄增加与 5 年 OS 降低相关（HR=1.040，95% CI=1.033-1.047）。与眼癌患者的总生存率相比，SDH 可能会影响就诊时的晚期 cT 分类和 30 天再入院，这凸显了需要眼科医生和公共卫生部门为解决 SDH 差异所做的努力。版权所有 © 2023。由 Elsevier Inc. 出版。

To evaluate the association between social determinants of health (SDH) with presentation, and outcomes in ocular cancer patients.The National Cancer Database was queried for primary clinical tumor (cT) classifications of T1-T4 N0M0 uveal melanoma, conjunctival melanoma, or retinoblastoma diagnosed between January 2006 and December 2017. Pearson Chi squared analysis assessed differences in SDH-related characteristics between cancer cohorts. Binary logistic regression with adjusted odds ratios (aOR) and multivariate Cox proportional hazards ratios (HR) with 95% confidence intervals (CI) were performed.Cross-sectional with a nationally representative sample RESULTS: 3968 uveal melanoma cases, 352 conjunctival melanoma cases, and 480 retinoblastoma cases were included. Differences in race, primary payer status, income quartile, population density, facility location, Charlson-Deyo comorbidity score, history of prior malignancy, cT classification at presentation, surgical treatment, radiotherapy, chemotherapy, 30-day readmission, and overall survival (OS) were observed among the cancers. Female sex (aOR=0.819, 95% CI=0.689-0.973) and top income quartile (aOR=0.691, 95% CI=0.525-0.908) had decreased likelihood of advanced cT classification at presentation. No insurance (aOR=1.736, 95% CI=1.159-2.601) and Medicaid primary payer status (aOR=1.875, 95% CI=1.323-2.656) had increased likelihood of advanced cT classification. Patients in rural areas (aOR=7.157, 95% CI=1.875-27.320) were more likely to be readmitted within 30 days following initial treatment. Increased age was associated with decreased 5-year OS (HR=1.040, 95% CI=1.033-1.047).SDH may influence advanced cT classification at presentation and 30-day readmission compared to overall survival in ocular cancer patients, highlighting the need for ophthalmologists and public health efforts to address disparities in SDH.Copyright © 2023. Published by Elsevier Inc.