这项研究设计了磁性纳米复合水凝胶珠，用于潜在的靶向抗癌口服给药系统。为此，在 Fe3O4 纳米粒子存在下，通过对苯二甲酸 (TPA) 和 (Fe(NO3)3·9H2O) 处理，通过原位方法合成了 Fe3O4/MIL-88(Fe) (FM) 纳米杂化物。然后用甘露糖作为抗癌受体对它们进行修饰，以实现靶向药物输送系统。加载甲氨蝶呤 (MTX) 后，在氯化钙交联剂存在下，将它们涂上 pH 敏感的果胶水凝胶珠，以便可以通过消化系统的酸性环境将纳米混合物转移到肠道。不同分析技术的结果表明材料被正确合成、涂覆和负载。设计的磁性纳米复合水凝胶珠表现出pH敏感性溶胀和药物释放速率，保护MTX免受胃酸性环境的影响。 MTT测试显示对结肠癌HT29细胞系具有良好的细胞毒性。值得注意的是，负载 MTX 的 FM 纳米杂化物与甘露糖 (MTX-MFM) 的功能化将其抗癌特性提高了约 20%。结果表明，所制备的新型磁性纳米复合水凝胶珠具有作为靶向抗癌口服给药系统的良好潜力。版权所有 © 2023 Elsevier B.V. 保留所有权利。

This study designed magnetic nanocomposite hydrogel beads for a potential targeted anticancer oral delivery system. To end this, nanohybrids of Fe3O4/MIL-88(Fe) (FM) were synthesized through in-situ method by the treatment of terephthalic acid (TPA) and (Fe(NO3)3·9H2O) in the presence of Fe3O4 nanoparticles. They were then modified with mannose sugar as an anticancer receptor to achieve a targeted drug delivery system. After loading methotrexate (MTX), they were coated with pH-sensitive pectin hydrogel beads in the presence of a calcium chloride crosslinker for possible transferring the nanohybrids to the intestine through the acidic environment of the digestive system. The results of different analysis techniques showed that the materials were properly synthesized, coated, and loaded. The designed magnetic nanocomposite hydrogel beads showed pH-sensitive swelling and drug release rate, protecting MTX from the acidic environment of the stomach. MTT test revealed a good cytotoxicity toward colon cancer HT29 cell lines. Remarkably, the functionalization of MTX-loaded FM nanohybrids with mannose (MTX-MFM) enhanced their anticancer properties up to about 20 %. The results recommended that the prepared novel magnetic nanocomposite hydrogel beads have a good potential to be used as a targeted anticancer oral delivery system.Copyright © 2023 Elsevier B.V. All rights reserved.