从三尖杉的树枝和叶子中分离出四种未描述的天然二萜木脂素和两种三尖杉烷二萜类化合物，以及七种已知化合物，包括两对对映体。通过光谱数据解释、手性相 HPLC 分析、NMR 计算和电子圆二色性分析阐明了它们的结构。评估了所有分离的化合物对三种人类肿瘤细胞系的细胞毒活性。其中，化合物8对MCF-7、HepG2和A549细胞系表现出最有效的活性，IC50值分别为2.83、4.75和2.77μM。版权所有©2023。由Elsevier Ltd.出版。

Four undescribed naturally diterpenolignans, and two cephalotane diterpenoids, along with seven known compounds, including two pairs of enantiomers, were isolated from the twigs and leaves of Cephalotaxus oliveri Mast. Their structures were elucidated via spectroscopic data interpretation, chiral-phase HPLC analysis, NMR calculations, and electronic circular dichroism analysis. All the isolated compounds were evaluated for their cytotoxic activities against three kinds of human tumor cell lines. Among them, compound 8 exhibited the most potent activities against MCF-7, HepG2 and A549 cell lines with IC50 values of 2.83, 4.75 and 2.77 μM, respectively.Copyright © 2023. Published by Elsevier Ltd.