孤立性纤维瘤（SFT）是一种行为多样的间叶性肿瘤，很少累及泌尿生殖道（GU）。大多数报告的病例都是孤立的病例报告。 STAT6 免疫组织化学是一种更新且可靠的诊断标记物。在两个大专机构的病理数据库中搜索了涉及 GU 道的 SFT。 STAT6 强弥漫核染色证实了所有 4 例患者的诊断，其中 1 例患者通过 NGS 证实了 NAB2::STAT6 融合。穿刺活检确诊两例，一例累及前列腺，另一例累及精囊。 1 例对应于盆腔肿块，与前列腺和膀胱不可分离并浸润。其余的则代表极其罕见的精索受累。在涉及 GU 器官的梭形细胞病变的鉴别诊断中，应考虑 SFT 的参与。 STAT6 强弥散核染色是一种重要的辅助工具，特别是在活检中。© 2023。作者获得 Springer-Verlag GmbH 德国（Springer Nature 旗下公司）的独家许可。

Solitary fibrous tumour (SFT) is a mesenchymal neoplasm with variable behaviour, very rarely involving the genitourinary (GU) tract. Most reported cases correspond to isolated case reports. STAT6 immunohistochemistry is a more recent and reliable diagnostic marker. The pathology database of two tertiary institutes was searched for SFTs involving the GU tract. STAT6 strong diffuse nuclear staining confirmed the diagnosis in all four cases, and the NAB2::STAT6 fusion was demonstrated by NGS in one case. Two cases were diagnosed in needle biopsy, one involving the prostate and the other involving the seminal vesicle. One case corresponded to a pelvic mass inseparable from and infiltrating the prostate and bladder. The remainder represented an exceedingly rare involvement of the spermatic cord. Involvement by a SFT should be considered in the differential diagnosis of spindle cell lesions involving GU organs. STAT6 strong diffuse nuclear staining is an important ancillary tool, particularly in a biopsy.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.