白芍 (RPA) 在中药中被广泛用于治疗胃肠道疾病、免疫调节疾病、癌症和许多其他疾病。它的一些活性成分包括芍药苷、白花苷、乳花苷和儿茶素。然而，它们的治疗效果因药代动力学较差、口服生物利用度低、半衰期短和水溶性差而受到影响。本研究成功制备了羟乙基纤维素接枝2-丙烯酰胺-2-甲基丙磺酸（HEC-g-AMPS）水凝胶，用于白芍固体分散体（RPA-SD）的控释。使用 UHPLC-Q-TOF-MS 分析在 RPA-SD 中总共鉴定出 43 种化合物。通过 FTIR、TGA、DSC、XRD 和 SEM 证实了水凝胶网络的形成。 48小时后，水凝胶在pH 1.2时的溶胀和药物释放（溶胀43.31％，药物释放81.70％）略高于pH 7.4时（溶胀27.73％，药物释放72.46％）。水凝胶的凝胶分数、药物释放时间和机械强度随着聚合物和单体浓度的增加而增加。此外，水凝胶是多孔的（孔隙率为 84.15%）且可生物降解（每周减重 8.9%）。此外，合成的水凝胶表现出优异的抗菌和抗氧化性能。

Radix Paeoniae Alba (RPA) has been used extensively in Chinese traditional medicine to treat gastrointestinal disorders, immune-modulating diseases, cancers, and numerous other conditions. A few of its active components include paeoniflorin, albiflorin, lactiflorin, and catechin. However, their therapeutic effectiveness is compromised by poor pharmacokinetic profiles, low oral bioavailability, short half-lives, and poor aqueous solubility. In this study, hydroxyethyl cellulose-grafted-2-acrylamido-2-methylpropane sulfonic acid (HEC-g-AMPS) hydrogels were successfully prepared for the controlled release of Radix Paeonia Alba-solid dispersion (RPA-SD). A total of 43 compounds were identified in RPA-SD using UHPLC-Q-TOF-MS analysis. The hydrogel network formation was confirmed by FTIR, TGA, DSC, XRD, and SEM. Hydrogels' swelling and drug release were slightly higher at pH 1.2 (43.31% swelling, 81.70% drug release) than at pH 7.4 (27.73% swelling, 72.46% drug release) after 48 h. The gel fraction, drug release time and mechanical strength of the hydrogels increased with increased polymer and monomer concentration. Furthermore, the hydrogels were porous (84.15% porosity) and biodegradable (8.9% weight loss per week). Moreover, the synthesized hydrogels exhibited excellent antimicrobial and antioxidative properties.