本研究探讨了口腔鳞状细胞癌（OSCC）组织中多效素（PTN）、尿激酶纤溶酶原激活剂（uPA）和糖蛋白非转移性黑色素瘤蛋白B（GPNMB）的表达及其与预后的相关性。 2017年2月至2020年1月，采用免疫组化方法检测93例OSCC患者癌组织及癌旁组织中PTN、uPA、GPNMB的表达情况。分析了OSCC联合检测的诊断价值及其与临床病理特征的关系，以及PTN、uPA和GPNMB的预后潜力。 OSCC 患者的癌组织表现出 PTN、uPA 和 GPNMB 的高表达。 PTN、uPA、GPNMB联合检测诊断和预后的AUC大于各指标单独检测的AUC。死亡组PTN、uPA、GPNMB的表达率高于存活组。表达 PTN、uPA 和 GPNMB 的患者 3 年生存率较低。 PTN表达是影响OSCC患者预后的危险因素。 OSCC组织中PTN、uPA、GPNMB表达率较高，其表达与淋巴结转移、肿瘤浸润深度等临床病理特征相关。各指标联合检测对患者预后具有预测价值。Copyright © 2023 the Author(s).由 Wolters Kluwer Health, Inc. 出版

This study investigated the expression of pleiotrophin (PTN), urokinase plasminogen activator (uPA), and glycoprotein nonmetastatic melanoma protein B (GPNMB) in oral squamous cell carcinoma (OSCC) tissues and their correlation with prognosis. From February 2017 to January 2020, PTN, uPA, and GPNMB expression in cancer tissues and adjacent tissues of 93 patients with OSCC was determined using immunohistochemistry. The diagnostic value of the combined detection of OSCC and its relationship with clinicopathological characteristics were analyzed, as well as the prognostic potential of PTN, uPA, and GPNMB. Cancer tissues from patients with OSCC exhibited high expression of PTN, uPA, and GPNMB. The AUC for the combined detection of PTN, uPA, and GPNMB for diagnosis and prognosis was greater than that of each index alone. The rates of expression of PTN, uPA, and GPNMB were higher in the death group than in the survival group. Patients with PTN, uPA, and GPNMB expression had lower 3-year survival rates. PTN expression was a risk factor affecting the prognosis of patients with OSCC. The rate of PTN, uPA, and GPNMB expression in OSCC tissues was high, and their expression was related to clinicopathological features such as lymph node metastasis and tumor invasion depth. The combined detection of each index has a predictive value for the prognosis of patients.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.