癌症治疗诊断学非常需要将靶向能力、成像功能和光热/光动力疗法结合到单一药物中。在此，我们开发了一种具有 N/P/S 共掺杂荧光碳纳米点（CND）的一站式纳米平台，用于肿瘤特异性光治疗。 CND 是使用癌细胞作为碳、氮、磷和硫源，通过一锅水热工艺制备的。所获得的N/P/S共掺杂CND在200-900 nm范围内表现出宽广的光吸收和具有高光稳定性的激发依赖性发射。重要的是，癌细胞来源的N/P/S共掺杂CND具有出色的生物相容性和天然内在的癌细胞靶向能力，以及在795 nm激光照射下的双重光热/光动力效应。此外，计算出光热转换效率和单线态氧（1O2）生成效率分别为52%和34%。这些特殊的特性使 CND 能够作为精细的治疗诊断剂，用于近红外治疗窗口内的靶向成像和光热-光动力协同治疗。这项工作中制备的 CND 有希望构建为通用的肿瘤光治疗平台。

Combining targeting ability, imaging function, and photothermal/photodynamic therapy into a single agent is highly desired for cancer theranostics. Herein, we developed a one-for-all nanoplatform with N/P/S-codoped fluorescent carbon nanodots (CNDs) for tumor-specific phototheranostics. The CNDs were prepared via a one-pot hydrothermal process using cancer cells as sources of carbon, nitrogen, phosphorus, and sulfur. The obtained N/P/S-codoped CNDs exhibit wide light absorption in the range of 200-900 nm and excitation-dependent emission with high photostability. Importantly, the cancer cell-derived N/P/S-codoped CNDs have outstanding biocompatibility and naturally intrinsic targeted ability for cancer cells as well as dual photothermal/photodynamic effects under 795 nm laser irradiation. Moreover, the photothermal conversion efficiency and singlet oxygen (1O2) generation efficiency were calculated to be 52 and 34%, respectively. These exceptional properties enable CNDs to act as fine theranostic agents for targeted imaging and photothermal-photodynamic synergistic therapy within the NIR therapeutic window. The CNDs prepared in this work are promising for construction as a universal tumor phototheranostic platform.