红树林内生真菌 Talaromyces sp. 次生代谢产物的研究。 SAF14 导致分离出两种新的聚酮化合物，(R)-3-(6,8-二羟基-7-甲氧基-1-氧代异色满-3-基)丙酸甲酯 (1)、(R)-3-(5、 8-二羟基-1-氧代异色满-3-基)丙酸(2)，以及四种已知的生物碱(3-6)。通过HR-ESI-MS和NMR数据的综合分析，阐明了新化合物的平面结构。通过将计算的 ECD 光谱与测量的 ECD 光谱进行比较来确定绝对构型。所有分离的化合物都针对三种人类癌细胞系进行了细胞毒性活性测试。已知的beauvericin (3)对A549、MCF-7和KB细胞系表现出很强的细胞毒活性，IC50值分别为5.36±2.49、1.96±1.09和4.46±0.68μM。

Investigation of secondary metabolites from the mangrove endophytic fungus Talaromyces sp. SAF14 led to the isolation of two new polyketides, methyl (R)-3-(6,8-dihydroxy-7-methoxy-1-oxoisochroman-3-yl)propanoate (1), (R)-3-(5,8- dihydroxy-1-oxoisochroman-3-yl)propanoic acid (2), together with four known alkaloids (3-6). The planar structures of new compounds were elucidated by comprehensive analysis of HR-ESI-MS and NMR data. The absolute configurations were determined by comparison of the calculated ECD spectrum with the measured one. All the isolated compounds were tested for cytotoxic activities against three human cancer cell lines. The known beauvericin (3) exhibited strong cytotoxic activity against A549, MCF-7, and KB cell lines with IC50 values of 5.36 ± 2.49, 1.96 ± 1.09 and 4.46 ± 0.68 μM, respectively.