基质金属蛋白酶11（MMP11）在细胞增殖、凋亡、肿瘤血管生成、迁移等基本过程中发挥着至关重要的作用。目前，很少有研究探讨 MMP11 在胰腺癌中与预后风险、诊断指标和免疫治疗相关的价值。本研究旨在探讨胰腺腺癌（PAAD）中MMP11与肿瘤免疫微环境的关系。我们选择了从癌症基因组图谱和基因型-组织表达中下载的临床样本和数据，此外，我们还使用其他在线数据进行进一步分析。通过全面的生物信息学研究，我们系统分析了MMP11在胰腺癌中的临床意义和表达水平。MMP11在许多癌症中过表达，MMP11较高的表达与胰腺癌较差的预后相关。相反，MMP11 的高甲基化与更好的总体生存率相关。 MMP11表达网络对PAAD的预后和免疫激活具有广泛影响。 MMP11的表达与多种肿瘤浸润免疫细胞显着相关。 PAAD 中 MMP11 表达与趋化因子之间也存在关联。 MMP11的高表达可能参与免疫细胞向肿瘤微环境的迁移。MMP11是胰腺癌患者的预后生物标志物，可能调节肿瘤免疫微环境。 MMP11在PAAD中的潜在作用和机制需要进一步探索。2024年胃肠肿瘤学杂志。版权所有。

Matrix metalloproteinase 11 (MMP11) plays a vital role in cell proliferation, apoptosis, tumor angiogenesis, migration, and other basic processes. Currently, few studies have examined the value of MMP11 in pancreatic cancer in relation to prognostic risk, diagnostic indicators, and immunotherapy. This study aims to explore the association between MMP11 and the tumor immune microenvironment in pancreatic adenocarcinoma (PAAD).We selected clinical samples and data downloaded from The Cancer Genome Atlas and Genotype-Tissue Expression, in addition, we use other online data for further analysis. Through a comprehensive bioinformatics investigation, we systematically analyzed the clinical significance and expression level of MMP11 in pancreatic cancer.MMP11 was overexpressed in many cancers, and a higher expression of MMP11 was associated with a poorer prognosis in pancreatic cancer. Conversely, the hypermethylation of MMP11 was associated with better overall survival. The MMP11 expression network had widespread effects on the prognosis and immune activation of PAAD. The expression of MMP11 was significantly associated with a variety of tumor-infiltrating immune cells. An association was also found between MMP11 expression and chemokines in PAAD. High MMP11 expression might be involved in immune cell migration to the tumor microenvironment.MMP11 is a prognostic biomarker for patients in pancreatic cancer and may regulate the tumor immune microenvironment. The potential effects and mechanisms of MMP11 in PAAD require further exploring.2024 Journal of Gastrointestinal Oncology. All rights reserved.