环状 RNA (CircRNA) 是非编码 RNA (ncRNA)，其特征是稳定的环状结构，可在转录和转录后水平调节基因表达。它们发挥着不同的作用，包括蛋白质相互作用、DNA 甲基化修饰、蛋白质编码潜力、假基因产生和 miRNA 海绵作用，所有这些都会影响各种生理过程。 CircRNA 通常在脑组织中高表达，其水平随神经发育而变化，这表明它们在神经系统疾病（例如神经胶质瘤）中具有重要意义。研究表明，与 PI3K 通路相关的 circRNA 表达与神经胶质瘤的各种临床特征相关。 circRNA 和 PI3K 通路之间存在相互作用，可调节神经胶质瘤细胞的增殖、分化、凋亡、炎症、血管生成和治疗抵抗等过程。此外，PI3K 通路相关的 circRNA 有潜力作为癌症诊断、预后和治疗的生物标志物。在本研究中，我们回顾了 PI3K 介导的 circRNA 的表达和细胞作用及其与神经胶质瘤癌发生和进展的关系的最新进展。我们还强调了 circRNA 作为神经胶质瘤诊断和预后生物标志物以及治疗靶点的重要性。版权所有 © 2024 Elsevier GmbH。版权所有。

Circular RNAs (CircRNAs) are non-coding RNAs (ncRNAs) characterized by a stable circular structure that regulates gene expression at both transcriptional and post-transcriptional levels. They play diverse roles, including protein interactions, DNA methylation modification, protein-coding potential, pseudogene creation, and miRNA sponging, all of which influence various physiological processes. CircRNAs are often highly expressed in brain tissues, and their levels vary with neural development, suggesting their significance in nervous system diseases such as gliomas. Research has shown that circRNA expression related to the PI3K pathway correlates with various clinical features of gliomas. There is an interact between circRNAs and the PI3K pathway to regulate glioma cell processes such as proliferation, differentiation, apoptosis, inflammation, angiogenesis, and treatment resistance. Additionally, PI3K pathway-associated circRNAs hold potential as biomarkers for cancer diagnosis, prognosis, and treatment. In this study, we reviewed the latest advances in the expression and cellular roles of PI3K-mediated circRNAs and their connections to glioma carcinogenesis and progression. We also highlighted the significance of circRNAs as diagnostic and prognostic biomarkers and therapeutic targets in glioma.Copyright © 2024 Elsevier GmbH. All rights reserved.