血液学和神经学表达 1 (HN1)，也称为木星微管相关同源物 1 (JPT1)，是一种高度保守的蛋白，在多种组织中广泛表达。在多种癌症中观察到 HN1 的异位升高，凸显了其在肿瘤发生和进展中的作用。蛋白质组学和转录组学均表明，HN1 与严重的疾病进展、不良预后和较短的总生存期密切相关。 HN1 参与癌细胞增殖和转移已被广泛研究。 HN1 的过度表达与肿瘤生长和疾病进展增加相关，而其缺失会导致细胞周期停滞和细胞凋亡。 HN1 在癌症进展中的关键作用，特别是在增殖、迁移和侵袭中，强调了其在癌症转移中的重要性。验证 HN1 抑制的有效性和安全性，以及开发确定患者 HN1 表达水平的诊断方法，对于将 HN1 靶向疗法转化为临床实践至关重要。总体而言，HN1 已成为癌症中有价值的预后标志物和治疗靶点，进一步的研究有可能通过阻止转移和增强治疗策略来改善患者的预后。版权所有 © 2024。由 Elsevier B.V. 出版。

Hematological and neurological expressed 1 (HN1), also known as Jupiter microtubule associated homolog 1 (JPT1), is a highly conserved protein with widespread expression in various tissues. Ectopic elevation of HN1 has been observed in multiple cancers, highlighting its role in tumorigenesis and progression. Both proteomics and transcriptomics reveal that HN1 is closely associated with severe disease progression, poor prognostic and shorter overall survival. HN1's involvement in cancer cell proliferation and metastasis has been extensively investigated. Overexpression of HN1 is associated with increased tumor growth and disease progression, while its depletion leads to cell cycle arrest and apoptosis. The pivotal role of HN1 in cancer progression, particularly in proliferation, migration, and invasion, underscores its significance in cancer metastasis. Validation of the efficacy and safety of HN1 inhibition, along with the development of diagnostic methods to determine HN1 expression levels in patients, is essential for the translation of HN1-targeted therapies into clinical practice. Overall, HN1 emerges as a valuable prognostic marker and therapeutic target in cancer, and further investigations hold the potential to improve patient outcomes by impeding metastasis and enhancing treatment strategies.Copyright © 2024. Published by Elsevier B.V.