经过多年的经典通路研究，hedgehog（HH）通路的组成、信息传递机制、与其他通路的串扰以及生理病理作用等已逐渐阐明。 HH 在肿瘤的形成和发展中也起着至关重要的作用。根据肿瘤表型解读的更新，整理了最新的相关研究，探讨HH通路通过基因突变和信号调控来调节不同肿瘤表型的具体机制。还对参与调节HH通路的药物和天然成分进行了综述； 5种已批准药物和在研药物通过阻断HH通路发挥功效，至少22种天然成分具有通过HH通路治疗肿瘤的潜力。然而，现有研究仍存在不足。本综述有事实依据证实了HH通路在未来癌症治疗中的巨大潜力。

In years of research on classical pathways, the composition, information transmission mechanism, crosstalk with other pathways, and physiological and pathological effects of hedgehog (HH) pathway have been gradually clarified. HH also plays a critical role in tumor formation and development. According to the update of interpretation of tumor phenotypes, the latest relevant studies have been sorted out, to explore the specific mechanism of HH pathway in regulating different tumor phenotypes through gene mutation and signal regulation. The drugs and natural ingredients involved in regulating HH pathway were also reviewed; five approved drugs and drugs under research exert efficacy by blocking HH pathway, and at least 22 natural components have potential to treat tumors by HH pathway. Nevertheless, there is a deficiency of existing studies. The present review confirmed the great potential of HH pathway in future cancer treatment with factual basis.