非裔美国男性的前列腺癌发病率和死亡率高于白人男性。越来越多的文献支持邻里劣势与侵袭性前列腺癌之间的关联，这种劣势对非裔美国男性的影响尤为严重。慢性压力和下游生物影响（例如，炎症增加）可能会导致这些关联。为了检查几个邻里劣势指标是否与压力相关基因的前列腺肿瘤 RNA 表达相关。这项横断面研究利用了非洲前列腺肿瘤转录组数据1992 年 8 月至 2021 年 1 月期间在马里兰大学医学中心接受根治性前列腺切除术的美国和白人前列腺癌男性。数据分析时间为 2023 年 5 月至 2024 年 4 月。使用诊断时的地址，2 个邻里剥夺指标（区域剥夺指数 [ADI]） ] 和经过验证的贝叶斯邻里剥夺指数）以及种族隔离指数 (RI) 和历史红线均应用于参与者的地址。使用电子病历确定自我报告的种族。使用线性回归对每个邻域指标总共评估了 105 个与压力相关的基因，并根据种族、年龄和手术年份进行了调整。逆境保守转录反应 (CTRA) 基因和压力相关信号基因均纳入其中。 共有 218 名男性（168 [77%] 非裔美国人，50 [23%] 白人），中位 (IQR) 年龄为 58 岁（53-63）岁也包括在内。非裔美国人参与者比白人参与者经历了更大的邻里劣势（中位 [IQR] ADI，115 [100-130] vs 92 [83-104]；中位 [IQR] RI，0.68 [0.34-0.87] vs 0.11 [0.06-0.14] ）。 ADI 与 11 个基因的表达呈正相关；多重比较调整后，HTR6（血清素途径）仍然显着（β = 0.003；SE，0.001；P < .001；Benjamini-Hochberg q值 = .01）。包括 HTR6 在内的多个基因与多个指标相关。我们观察到 CTRA 中 5 个促炎基因的表达较高，邻域劣势较大（例如 CXCL8 和 ADI，β = 0.008；SE，0.003；P = .01；q 值 = .21）。居住在贫困社区的男性前列腺肿瘤中一些与压力相关的基因表达较高。这项研究是第一个提出邻里劣势与前列腺肿瘤 RNA 表达相关的研究之一。需要在更大规模的研究中进行更多研究，以复制研究结果，并进一步研究邻近因素、肿瘤生物学和侵袭性前列腺癌之间的相互关系，以便为减少差异的干预措施提供信息。

African American men experience greater prostate cancer incidence and mortality than White men. Growing literature supports associations of neighborhood disadvantage, which disproportionately affects African American men, with aggressive prostate cancer; chronic stress and downstream biological impacts (eg, increased inflammation) may contribute to these associations.To examine whether several neighborhood disadvantage metrics are associated with prostate tumor RNA expression of stress-related genes.This cross-sectional study leveraged prostate tumor transcriptomic data for African American and White men with prostate cancer who received radical prostatectomy at the University of Maryland Medical Center between August 1992 and January 2021. Data were analyzed from May 2023 to April 2024.Using addresses at diagnosis, 2 neighborhood deprivation metrics (Area Deprivation Index [ADI] and validated bayesian Neighborhood Deprivation Index) as well as the Racial Isolation Index (RI) and historical redlining were applied to participants' addresses. Self-reported race was determined using electronic medical records.A total of 105 stress-related genes were evaluated with each neighborhood metric using linear regression, adjusting for race, age, and year of surgery. Genes in the Conserved Transcriptional Response to Adversity (CTRA) and stress-related signaling genes were included.A total of 218 men (168 [77%] African American, 50 [23%] White) with a median (IQR) age of 58 (53-63) years were included. African American participants experienced greater neighborhood disadvantage than White participants (median [IQR] ADI, 115 [100-130] vs 92 [83-104]; median [IQR] RI, 0.68 [0.34-0.87] vs 0.11 [0.06-0.14]). ADI was positively associated with expression for 11 genes; HTR6 (serotonin pathway) remained significant after multiple-comparison adjustment (β = 0.003; SE, 0.001; P < .001; Benjamini-Hochberg q value = .01). Several genes, including HTR6, were associated with multiple metrics. We observed higher expression of 5 proinflammatory genes in the CTRA with greater neighborhood disadvantage (eg, CXCL8 and ADI, β = 0.008; SE, 0.003; P = .01; q value = .21).In this cross-sectional study, the expression of several stress-related genes in prostate tumors was higher among men residing in disadvantaged neighborhoods. This study is one of the first to suggest associations of neighborhood disadvantage with prostate tumor RNA expression. Additional research is needed in larger studies to replicate findings and further investigate interrelationships of neighborhood factors, tumor biology, and aggressive prostate cancer to inform interventions to reduce disparities.