由于过去十年来世界各地癌症发病率上升，卫生保健工作者面临着重大挑战。在各种形式的恶性肿瘤中，皮肤癌是最常见的，因此需要创建一种有效且安全的皮肤癌治疗方法，可以提供靶向和位点特异性的肿瘤渗透，并减少意外的全身毒性。因此，纳米载体被用来解决传统抗癌药物输送方法的问题。侵入体是基于脂质的纳米囊泡，含有少量萜烯和乙醇或萜烯混合物，可以更有效地渗透皮肤。与其他脂质纳米载体相比，侵袭体渗透皮肤的速度要快得多。侵袭体具有许多优点，包括提高药物有效性、更高的依从性、患者便利性、先进的设计、多功能性、增强的靶向能力、非侵入性递送方法、联合治疗的潜力以及克服生物屏障的能力。这些属性使侵袭体成为未来癌症治疗的一个有前途的创新平台。本综述以新颖的组织方案提供了对侵袭体的见解，并结合了最新的癌症研究，包括其组成、历史发展和制备方法、涉及各种制剂变量影响的渗透机制以及抗癌机制和应用的分析。 invasomes.© 2024 Walter de Gruyter GmbH，柏林/波士顿。

Health care workers have faced a significant challenge because of the rise in cancer incidence around the world during the past 10 years. Among various forms of malignancy skin cancer is most common, so there is need for the creation of an efficient and safe skin cancer treatment that may offer targeted and site-specific tumor penetration, and reduce unintended systemic toxicity. Nanocarriers have thus been employed to get around the issues with traditional anti-cancer drug delivery methods. Invasomes are lipid-based nanovesicles having small amounts of terpenes and ethanol or a mixture of terpenes and penetrate the skin more effectively. Compared to other lipid nanocarriers, invasomes penetrate the skin at a substantially faster rate. Invasomes possess a number of advantages, including improved drug effectiveness, higher compliance, patient convenience, advanced design, multifunctionality, enhanced targeting capabilities, non-invasive delivery methods, potential for combination therapies, and ability to overcome biological barriers,. These attributes position invasomes as a promising and innovative platform for the future of cancer treatment. The current review provides insights into invasomes, with a fresh organizational scheme and incorporates the most recent cancer research, including their composition, historical development and methods of preparation, the penetration mechanism involving effect of various formulation variables and analysis of anticancer mechanism and the application of invasomes.© 2024 Walter de Gruyter GmbH, Berlin/Boston.