乳腺癌是全球和美国女性中最常见的癌症；然而，其在美国附属太平洋岛屿 (USAPI) 的六个地区的发病率仍然较少。我们使用不同的人群估计值分析了基于人口的癌症登记处的数据，以计算 USAPI 中 20 岁以上女性的乳腺癌发病率。计算比率和 95% 置信区间 (CI)，以比较 USAPI 和美国（50 个州和哥伦比亚特区）之间的发病率。2007 年至 2020 年，USAPI 诊断出 1118 例新乳腺癌病例，其中66.3% (n = 741) 的病例发生在关岛。 USAPI 的年龄标准化发病率为每 100,000 名女性 66.4 至 68.7 例，关岛每 100,000 名女性年龄标准化发病率为 101.1-110.5。与美国相比，USAPI 的发病率较低，比率范围为 0.38（95% CI：0.36，0.40）至 0.39（95% CI：0.37，0.42）。 USAPI（48.7%）的晚期癌症比例明显高于美国（34.0%），特别是密克罗尼西亚联邦（78.7%）和帕劳（73.1%）。乳腺癌发病率较低USAPI 高于美国；然而，晚期诊断的比例却高得不成比例。低发病率和晚期癌症可能预示着筛查、癌症监测以及医疗保健获取和资源方面的挑战。扩大及时乳腺癌筛查、诊断和治疗的范围可以降低晚期癌症的比例并提高 USAPI 的生存率。版权所有 © 2024 Elsevier Ltd。保留所有权利。

Breast cancer is the most common cancer diagnosed among women globally and in the United States (US); however, its incidence in the six US-Affiliated Pacific Islands (USAPI) remains less characterized.We analyzed data from a population-based cancer registry using different population estimates to calculate incidence rates for breast cancer among women aged >20 years in the USAPI. Rate ratios and 95 % confidence intervals (CI) were calculated to compare incidence rates between the USAPI and the US (50 states and the District of Columbia).From 2007-2020, 1118 new cases of breast cancer were diagnosed in the USAPI, with 66.3 % (n = 741) of cases reported in Guam. Age-standardized incidence rates ranged from 66.4 to 68.7 per 100,000 women in USAPI and 101.1-110.5 per 100,000 women in Guam. Compared to the US, incidence rates were lower in USAPI, with rate ratios ranging from 0.38 (95 % CI: 0.36, 0.40) to 0.39 (95 % CI: 0.37, 0.42). The proportion of late-stage cancer was significantly higher in the USAPI (48.7 %) than in the US (34.0 %), particularly in the Federated States of Micronesia (78.7 %) and Palau (73.1 %).Breast cancer incidence rates were lower in the USAPI than in the US; however, late-stage diagnoses were disproportionately higher. Low incidence and late-stage cancers may signal challenges in screening, cancer surveillance, and health care access and resources. Expanding access to timely breast cancer screening, diagnosis, and treatment could reduce the proportion of late-stage cancers and improve survival in the USAPI.Copyright © 2024 Elsevier Ltd. All rights reserved.